APOPTOTIC AND MITOTIC ACTIVITY IN SQUAMOUS CELL CARCINOMA CELLS AFTER COMBINED MODALITY TREATMENT WITH γ-IRRADIATION AND DIBROMODULCITOL

Authors

  • H. Kraxner,

    1. Department of Otorhinolaryngology and Head and Neck Surgery, Semmelweis University, Szigony u. 36, H-1083, Budapest, Hungary
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  • L. Tamás,

    1. Jahn Ferenc Teaching Hospital, Dept of ENT, Semmelweis University Affiliate, Köves u. 2–4, H-1204, Budapest, Hungary
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  • G. Sáfrány,

    1. National Research Institute for Radiobiology and Radiohygiene, Anna u. 5, H-1221, Budapest, Hungary
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  • O. Ribári,

    1. Department of Otorhinolaryngology and Head and Neck Surgery, Semmelweis University, Szigony u. 36, H-1083, Budapest, Hungary
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  • I. Oláh,

    1. 1st Institute of Pathology and Experimental Cancer Research, Molecular Pathology Research Group, Joint Research Organisation of the Hungarian Academy of Sciences and Semmelweis University, Üllõi u. 26, H-1085, Budapest, Hungary
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  • E. Hidvégi,

    1. National Research Institute for Radiobiology and Radiohygiene, Anna u. 5, H-1221, Budapest, Hungary
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  • G. Répássy,

    1. Department of Otorhinolaryngology and Head and Neck Surgery, Semmelweis University, Szigony u. 36, H-1083, Budapest, Hungary
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  • B. Szende

    Corresponding author
    1. 1st Institute of Pathology and Experimental Cancer Research, Molecular Pathology Research Group, Joint Research Organisation of the Hungarian Academy of Sciences and Semmelweis University, Üllõi u. 26, H-1085, Budapest, Hungary
      To whom correspondence should be addressed. E-mail: bszende@korb1/sote.hu
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To whom correspondence should be addressed. E-mail: bszende@korb1/sote.hu

Abstract

A-431 squamous cell carcinoma cells were treated in vitro with either 4Gy radiatio of 15 (or 45) μg/ml dibromodulcitol (DBD), as well as with combined 4Gy irradiation and DBD, with the latter as either a pretreatment or post-treatment. DBD alone or in combination with radiation had a greater effect on cell proliferation than the effect of radiation alone. The difference is due to a higher level of apoptosis induced by DBD, especially in conjunction with radiation. Such a combination may therefore be useful in the treatment of squamous cell carcinoma, which in general responds poorly to radiation therapy.

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