MYOSIN II REDISTRIBUTION DURING REAR RETRACTION AND THE ROLE OF FILAMENT ASSEMBLY AND DISASSEMBLY

Authors

  • Gudrun Koehl,

    1. Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892, U.S.A.
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    • Klinik und Poliklinik für Chirurgie, Universitätsklinikum Regensburg, Forschungsbau H4, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany.

  • James G. Mcnally

    Corresponding author
    1. Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892, U.S.A.
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To whom correspondence should be addressed: James G. McNally, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892, U.S.A. mcnallyj@exchange.nih.gov

Abstract

The literature to date suggests a role for myosin II in rear retraction, including evidence that myosin undergoes a characteristic ‘C’-to-spot redistribution at the cell posterior which is associated with retraction. Here we investigate the mechanism of both retraction and the ‘C’-to-spot using

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