OVER-EXPRESSION OF K-FGF OR bFGF RESULTS IN ALTERED EXPRESSION OF MATRIX METALLOPROTEINASES: CORRELATIONS WITH MALIGNANT PROGRESSION AND CELLULAR INVASION

Authors

  • James Lo,

    1. Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital and University of Toronto, Toronto, Canada, M5B 1A6
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  • Robert A. R. Hurta

    Corresponding author
    1. Department of Biology, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island, Canada, C1A 4P3
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Correspondence to: Robert Hurta; Tel: 902-566-0476; Fax: 902-566-0740; rhurta@upei.ca

Abstract

Matrix metalloproteinase (MMP) expression was investigated in NIH-3T3 fibroblasts that secrete K-FGF and in NIH-3T3 cells which express chimeric bFGF with a signal sequence targeting bFGF to the secretory pathway. Correlations between altered MMPs' and other proteases' expression and malignant potential were determined. Correlations between the expression of MMPs and the invasion ability of K-FGF and bFGF over-expressing cells were also determined. The resulting correlation between alterations in proteases and malignant progression supports a model which suggests that growth factor modulation of protease expression is part of the altered growth regulatory program associated with cellular transformation and malignant progression.

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