INSULIN-MEDIATED TYROSINE PHOSPHORYLATION OF MYOSIN HEAVY CHAIN AND CONCOMITANT ENHANCED ASSOCIATION OF C-TERMINAL SRC KINASE DURING SKELETAL MUSCLE DIFFERENTIATION

Authors

  • Hira Lal Goel,

    1. Signal Transduction Research Laboratory, Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab, 160 062, India
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  • Chinmoy Sankar Dey

    Corresponding author
    1. Signal Transduction Research Laboratory, Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar, Punjab, 160 062, India
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To whom correspondence should be addressed: Tel: +91(0) 172-214687; E-mail: niper@chd.nic.in (Attn: Dr Dey) CC to: ars1@glide.net.in

Abstract

In this study, we present for the first time: (1) evidence regarding tyrosine phosphorylation of myosin heavy chain, (2) evidence that insulin can phosphorylate myosin, (3) association of myosin with Csk, a signalling molecule, (4) modulation of this association by insulin, and (5) evidence that these interactions are associated with skeletal muscle differentiation.

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