Estrogen Replacement Therapy and Endometrial Cancer: The Elusive Link


  • Margaret Maggio

    Corresponding author
    1. Margaret Maggio is a second-year graduate student at the University of Illinois at the Medical Center and has recently completed the clinical component of the nurse-midwifery program. She received her B.S.N. degree from Loyola University of Chicago and worked as a staff nurse in labor and delivery at Evanston Hospital, Evanston, Illinois. This year she will join an obstetrician in private practice.
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Address correspondence to: Ms. Margaret Maggio, 1337 Highridge, Westchester, Illinois 60153.


Estrogen replacement therapy has been in widespread use in the past two decades in the treatment of symptoms commonly associated with the perimenopausal period. In recent years, several retrospective studies have indicated that an association between estrogen replacement therapy and endometrial cancer may exist. These research findings and their critiques are reviewed. Implications for further use of estrogen replacement therapy are delineated.