This study was performed to assess the sexual knowledge and attitudes of student nurse-midwives (SNMs). All SNMs enrolled in nurse-midwifery programs between November 1981 and February 1982 were surveyed. Instruments used included the Sexual Knowledge and Attitude Test and a demographic and background data questionnaire. Significant findings included generally liberal attitudes toward heterosexual relations, autoeroticism, and the rejection of common sexual myths; more conservative attitudes toward abortion were found. No significant differences in knowledge and/or attitudes were revealed when groups were compared on the basis of age, marital status, level in nurse-midwifery programs, or length of time in nursing. Significant differences were found when comparisons were made based on religious preference, degree of urbanization, educational level, type of nurse-midwifery program, and prior human sexuality education. The implications of these differences for nurse-midwifery practice, education, and research are discussed.