Edna M. McKim, RN, MN, is a clinical nurse specialist. She has had experience as a staff nurse and teacher in the perinatal area and has been the coordinator of the Newfoundland and Labrador Perinatal Program, St. John's, Newfoundland, Canada. She is currently an assistant professor, School of Nursing, Memorial University of Newfoundland. She is a member of Sigma Theta Tau and NAACOG.
CAFFEINE AND ITS EFFECTS ON PREGNANCY AND THE NEONATE
Article first published online: 6 JAN 2011
1991 American College of Nurse Midwives
Journal of Nurse-Midwifery
Volume 36, Issue 4, pages 226–231, July-August 1991
How to Cite
McKim, E. M. (1991), CAFFEINE AND ITS EFFECTS ON PREGNANCY AND THE NEONATE. Journal of Nurse-Midwifery, 36: 226–231. doi: 10.1016/0091-2182(91)90083-2
- Issue published online: 6 JAN 2011
- Article first published online: 6 JAN 2011
In animal studies, fetal loss, decreased fetal weight and size, and major skeletal defects have been reported when dosages of more than 80 mg/kg of caffeine were used. Human epidemiologic studies that examine the relationship between caffeine use and congenital abnormalities are not conclusive; however, there is some evidence to suggest a caffeine effect upon fetal growth patterns. Because caffeine drinking is so often associated with the use of other drugs such as tobacco, it is difficult to ascertain which drug has the effect on growth, or if it is a combined effect from both drugs. A tripling of the half-life of caffeine in the last two trimesters of pregnancy resulting in much higher caffeine blood levels for both mother and fetus, combined with the neonate's inability to metabolize caffeine, could account for the indications of neonatal caffeine withdrawal observed in the first week after birth.