In the past few years, endometrial biopsy has become a procedure that can be performed on an outpatient basis, causing relatively minor discomfort to the client. It is frequently used as a method of dating the endometrium but has also become an important tool in screening for endometrial hyperplasia and carcinoma. It is also recommended by some as a part of the routine screening for women on hormone replacement therapy. This article presents the indications, contraindications, and technical procedure for performing endometrial biopsies in the office setting. In addition, complications and follow-up care are discussed.