Nurse-mid wives are sometimes required to intervene in the normal process of labor. Numerous clinical trials have investigated the use of prostaglandins for induction of labor. Research indicates the use of prostaglandins to be a safe and effective method of induction of labor with favorable results when compared with the more traditional use of oxytocin. Patient acceptance appears to be favorable because of the reduced need for restrictive and invasive methods of monitoring and administration that accompany intravenous oxytocin. Thus, the use of prostaglandins for induction of labor offers nurse-midwives an attractive alternative to the use of oxytocin when induction is medically indicated. This article provides a description of the biochemical effects of prostaglandins on the uterus and cervix, development and clinical use of prostaglandin preparations, indications for use of induction, and potential for utilization in nurse-midwifery practice.