HUMAN IMMUNODEFICIENCY VIRUS AND AIDS

1993 Update

Authors

  • Jonathan Allen Cohn MD

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    • Jonathan Allen Cohn, MD, is the Codirector of the Adult HIV Program, Director of the Maryland AIDS Professional Education Center, and Assistant Professor in the Infectious Disease Division of the University of Maryland Medical Center in Baltimore. He participates in studies of women with HIV through the Community-Based Clinical Trials Network of the American Foundation for AIDS Research and through the Division of AIDS Treatment Research Initiative of the National Institute of Allergy and Infectious Disease.


  • Supported in part by Maryland State contract DHMH92-778 and by grant 1 D35 PE00105-01 through the Health Resources and Services Administration, Bureau of Health Professions, Department of Medicine.

2 University of Maryland Medical Center, 22 South Greene Street Box 243, Baltimore, MD 21201–1595.

ABSTRACT

Research into the biology of human immunodeficiency virus (HIV), and the immunopathogenesis of HIV disease, is proceeding rapidly. New therapies are being developed based on this new knowledge. Meanwhile, the proportion of women in the United States with AIDS is rising, and heterosexual spread is the fastest rising mode of transmission. Overall survival with HIV and AIDS appears to be similar in women and men receiving similar treatment. However, the results of several population-based studies indicate that women are less likely to have received antiretroviral therapy than have men. Gynecologic complications of HIV, including recurrent and refractory vaginal candidiasis and an increased frequency of cervical dysplasia and carcinoma, have only recently been recognized. There are still little data on the effect of pregnancy on the course of HIV disease in women. The implications of current knowledge for prevention and treatment of HIV in women are discussed.

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