Mesial temporal lobe epilepsy: A pathological replay of developmental mechanisms?

Authors

  • Ivan Cohen,

    1. Cortex et Epilepsie, INSERM EMI 0224, CHUPS, Université Paris VI, 105 boulevard de l'Hôpital, 75013 Paris, France
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    • Division of Neuroscience, Baylor College of Medicine, Houston, TX.

  • Vincent Navarro,

    1. Cortex et Epilepsie, INSERM EMI 0224, CHUPS, Université Paris VI, 105 boulevard de l'Hôpital, 75013 Paris, France
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  • Caroline Le Duigou,

    1. Cortex et Epilepsie, INSERM EMI 0224, CHUPS, Université Paris VI, 105 boulevard de l'Hôpital, 75013 Paris, France
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  • Richard Miles

    Corresponding author
    1. Cortex et Epilepsie, INSERM EMI 0224, CHUPS, Université Paris VI, 105 boulevard de l'Hôpital, 75013 Paris, France
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Tel +33-1-42-86-38-26; Fax +33-1-42-86-38-05. Email-address: rmiles@biomedicale.univ-paris5.fr

Abstract

Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms.

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