• [1]
    Van Delden, C., Iglewski, B.H. (1998) Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg. Infect. Dis. 4, 551560.
  • [2]
    Pesci, E.C. and Iglewski, B.H. (2003) Quorum sensing. In: Bacterial Protein Toxins (Burns, D.L., Barbieri, J.T., Iglewski, B.H. and Rappuoli, R., Eds.), pp. 55–65. ASM Press, Washington, DC.
  • [3]
    Gambello, M.J., Iglewski, B.H. (1991) Cloning and characterization of the Pseudomonas aeruginosa lasR gene: a transcriptional activator of elastase expression. J. Bacteriol. 173, 30003009.
  • [4]
    Ochsner, U.A., Koch, A.K., Fiechter, A., Reiser, J. (1994) Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J. Bacteriol. 176, 20442054.
  • [5]
    Ochsner, U.A., Reiser, J. (1995) Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92, 64246428.
  • [6]
    Passador, L., Cook, J.M., Gambello, M.J., Rust, L., Iglewski, B.H. (1993) Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 260, 11271130.
  • [7]
    Winson, M.K., Camara, M., Latifi, A., Foglino, M., Chhabra, S.R., Daykin, M., Bally, M., Chapon, V., Salmond, G.P.C., Bycroft, B.W., Lazdunski, A., Stewart, G.S.A.B., Williams, P. (1995) Multiple N-acyl-l-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92, 94279431.
  • [8]
    Pearson, J.P., Gray, K.M., Passador, L., Tucker, K.D., Eberhard, A., Iglewski, B.H., Greenberg, E.P. (1994) Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc. Natl. Acad. Sci. USA 91, 197201.
  • [9]
    Pearson, J.P., Passador, L., Iglewski, B.H., Greenberg, E.P. (1995) A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 92, 14901494.
  • [10]
    Schuster, M., Lostroh, C.P., Ogi, T., Greenberg, E.P. (2003) Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J. Bacteriol. 185, 20662079.
  • [11]
    Wagner, V.E., Bushnell, D., Passador, L., Brooks, A.I., Iglewski, B.H. (2003) Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J. Bacteriol. 185, 20802095.
  • [12]
    Whiteley, M., Lee, K.M., Greenberg, E.P. (1999) Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 96, 1390413909.
  • [13]
    Pesci, E.C., Milbank, J.B., Pearson, J.P., McKnight, S., Kende, A.S., Greenberg, E.P., Iglewski, B.H. (1999) Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 96, 1122911234.
  • [14]
    Collier, D.N., Anderson, L., McKnight, S.L., Noah, T.L., Knowles, M., Boucher, R., Schwab, U., Gilligan, P., Pesci, E.C. (2002) A bacterial cell to cell signal in the lungs of cystic fibrosis patients. FEMS Microbiol. Lett. 215, 4146.
  • [15]
    Gallagher, L.A., Manoil, C. (2001) Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning. J. Bacteriol. 183, 62076214.
  • [16]
    Gallagher, L.A., McKnight, S.L., Kuznetsova, M., Pesci, E.C., Manoil, C. (2002) Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa. J. Bacteriol. 184, 64726480.
  • [17]
    McKnight, S.L., Iglewski, B.H., Pesci, E.C. (2000) The Pseudomonas quinolone signal (PQS) regulates rhl quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 182, 27022708.
  • [18]
    D'Argenio, D.A., Calfee, M.W., Rainey, P.B., Pesci, E.C. (2002) Autolysis and autoaggregation in Pseudomonas aeruginosa colony morphology mutants. J. Bacteriol. 184, 64816489.
  • [19]
    Ohman, D.E., Cryz, S.J., Iglewski, B.H. (1980) Isolation and characterization of a Pseudomonas aeruginosa PAO mutant that produces altered elastase. J. Bacteriol. 142, 836842.
  • [20]
    Pearson, J.P., Pesci, E.C., Iglewski, B.H. (1997) Roles of Pseudomonas aeruginosa las and rhl quorum sensing systems in control of elastase and rhamnolipid biosynthesis genes. J. Bacteriol. 179, 57565767.
  • [21]
    Miller, J. (1972) Experiments in Molecular Genetics, pp. 352–355. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
  • [22]
    Calfee, M.W., Coleman, J.P., Pesci, E.C. (2001) Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 98, 1163311637.
  • [23]
    Rust, L., Pesci, E.C., Iglewski, B.H. (1996) Analysis of the Pseudomonas aeruginosa elastase (lasB) regulatory region. J. Bacteriol. 178, 11341140.
  • [24]
    Whiteley, M., Greenberg, E.P. (2001) Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes. J. Bacteriol. 183, 55295534.
  • [25]
    Cao, H., Krishnan, G., Goumnerov, B., Tsongalis, J., Tompkins, R., Rahme, L.G. (2001) A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism. Proc. Natl. Acad. Sci. USA 98, 1461314618.
  • [26]
    Essar, D.W., Eberly, L., Hadero, A., Crawford, I.P. (1990) Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications. J. Bacteriol. 172, 884900.
  • [27]
    Pesci, E.C., Pearson, J.P., Seed, P.C., Iglewski, B.H. (1997) Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 179, 31273132.
  • [28]
    Chugani, S.A., Whiteley, M., Lee, K.M., D'Argenio, D., Manoil, C., Greenberg, E.P. (2001) QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 98, 27522757.
  • [29]
    Ledgham, F., Ventre, I., Soscia, C., Foglino, M., Sturgis, J.N., Lazdunski, A. (2003) Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR. Mol. Microbiol. 48, 199210.
  • [30]
    Guina, T., Purvine, S.O., Yi, E.C., Eng, J., Goodlett, D.R., Aebersold, R., Miller, S.I. (2003) Quantitative proteomic analysis indicates increased synthesis of a quinolone by Pseudomonas aeruginosa isolates from cystic fibrosis airways. Proc. Natl. Acad. Sci. USA 100, 27712776.
  • [31]
    Holloway, B.W., Krishnapillai, V., Morgan, A.F. (1979) Chromosomal genetics of Pseudomonas. Microbiol. Rev. 43, 73102.
  • [32]
    Brint, J.M., Ohman, D.E. (1995) Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J. Bacteriol. 177, 71557163.
  • [33]
    Huang, B., Whitchurch, C.B., Croft, L., Beatson, S.A., Mattick, J.S. (2000) A minimal tiling path cosmid library for functional analysis of the Pseudomonas aeruginosa PAO1 genome. Microb. Comp. Genomics 5, 189203.