• 1
    Bachrach NM, Valhmu WB, Stazzone E, Ratcliffe A, Lai WM, Mow VC. Changes in proteoglycan synthesis of chondrocytes in articular cartilage are associated with the time-dependent changes in their mechanical environment. J Biomech 1995; 28: 15619.
  • 2
    Bolander ME. Regulation of fracture repair by growth factors. Proc Soc Exp Biol Med 1992; 200: 16570.
  • 3
    Burger EH, Klein-Nulend J, Veldhuijzen JP. Modulation of osteogenesis in fetal bone rudiments by mechanical stress in vitro. J Biomech 1991; 24(Suppl 1): 1019.
  • 4
    Burton-Wurster N, Vernier-Singer M, Farquhar T, Lust G. Effect of compressive loading and unloading on the synthesis of total protein, proteoglycan, and fibronectin by canine cartilage explants. J Orthop Res 1993; 11: 71729.
  • 5
    Buschmann MD, Gluzband YA, Grodzinsky AJ, Hunziker EB. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J Cell Sci 1995; 108: 1497508.
  • 6
    Carrino DA, Arias JL, Caplan AI. A spectrophotometric modification of a sensitive densitometric Safranin O assay for glycosaminoglycans. Biochem Int 1991; 24: 48595.
  • 7
    Carter DR, Beaupre GS, Giori NJ, Helms JA. Mechanobiology of skeletal regeneration. Clin Orthop 1998; 355: 41S55S.
  • 8
    Carter DR, Blenman PR, Beaupre GS. Correlations between mechanical stress history and tissue differentiation in initial fracture healing. J Orthop Res 1988; 6: 73648.
  • 9
    Carver SE, Heath CA. Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. Biotechnol Bioeng 1999; 62: 16674.
  • 10
    Edelstein-Keshet L, Ermentrout GB. Contact response of cells can mediate morphogenetic pattern formation. Differentiation 1990; 45: 14759.
  • 11
    Elder SH, Kumura JH, Soslowsky LJ, Lavagnino M, Goldstein SA. Effect of compressive loading on chondrocyte differentiation in agarose cultures of chick limb-bud cells. J Orthop Res 2000; 18: 7886.
  • 12
    Ellison BE, Carter DR, Smith RL. Effects of variable duration intermittent hydrostatic pressure on cartilage glycosaminoglycan synthesis. Trans Orthop Res Soc 1994; 19: 486.
  • 13
    Farquhar T, Xia Y, Mann K, Bertram J, Burton-Wurster N, Jelinski L, et al. Swelling and fibronectin accumulation in articular cartilage explants after cyclical impact. J Orthop Res 1996; 14: 41723.
  • 14
    Fell HB. The histogenesis of cartilage and bone in the long bones of the embryonic fowl. J Morphol Physiol 1925; 40: 41759.
  • 15
    Hall AC, Urban JPG, Gehl KA. The effects of hydrostatic pressure on matrix synthesis in articular cartilage. J Orthop Res 1991; 9: 110.
  • 16
    Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 1998; 238: 26572.
  • 17
    Kim YJ, Grodzinsky AJ, Plaas AH. Compression of cartilage results in differential effects on biosynthetic pathways for aggregan, link protein, and hyaluronan. Arch Biochem Biophys 1996; 328: 33140.
  • 18
    Kim YJ, Sah RL, Doong JY, Grodzinsky AJ. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 1988; 174: 16876.
  • 19
    Kim YJ, Sah RL, Grodzinsky AJ, Plaas AH, Sandy JD. Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. Arch Biochem Biophys 1994; 311: 112.
  • 20
    Lippiello L, Kaye C, Neumata T, Mankin HJ. In vitro metabolic response of articular cartilage segments to low levels of hydrostatic pressure. Conn Tiss Res 1985; 13: 99107.
  • 21
    Mow VC, Ratcliffe A, Poole AR. Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. Biomaterials 1992; 13: 6797.
  • 22
    Ngwa GA, Maini PK. Spatio-temporal patterns in a mechanical model for mesenchymal morphogenesis. J Math Biol 1995; 33: 489520.
  • 23
    Palmoski MP, Brandt KD. Effects of static and cyclic compressive loading on articular cartilage plugs in vitro. Arthritis Rheum 1984; 27: 67581.
  • 24
    Shapiro F, Koide S, Glimcher MJ. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg 1993; 75A: 53253.
  • 25
    Smith RL, Rusk SF, Ellison BE, Wessells P, Tsuchiya K, Carter DR, et al. In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure. J Orthop Res 1996; 14: 5360.
  • 26
    Stegemann H, Stalder. Determination of hydroxyproline. Clin Chim Acta 1967; 18: 267.
  • 27
    Suh JK, Baek GH, Aroen A, Malin CM, Niyibizi C, Evans CH, et al. Intermittent sub-ambient interstitial hydrostatic pressure as a potential mechanical stimulator for chondrocyte metabolism. Osteoarth Cartil 1999; 7: 7180.
  • 28
    Tägil M, Aspenberg P. Cartilage induction by controlled mechanical stimulation in vivo. J Orthop Res 1999; 17: 2004.
  • 29
    Takahashi I, Nuckolls GH, Takahashi K, Tanaka O, Semba I, Dashner R, et al. Compressive force promotes sox9, type II collagen and aggregan and inhibits IL-1β expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells. J Cell Sci 1998; 111: 206776.
  • 30
    Torzilli PA, Grigiene R, Huang C, Friedman SM, Doty SB, Boskey AL, et al. Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system. J Biomech 1997; 30: 19.
  • 31
    van Kampen GPJ, Veldhuijzen JP, Kuijer R, van de Stadt RJ, Schipper CA. Cartilage response to mechanical force in high-density chondrocyte cultures. Arthritis Rheum 1985; 28: 41924.
  • 32
    Yoo JU, Barthel TS, Nishimura K, Solchaga L, Caplan AI, Goldberg VM, et al. The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells. J Bone Joint Surg [Am] 1998; 80: 174557.