• 1
    Brekke J, Toth JM. Principles of tissue engineering applied to programmable osteogenesis. J Biomed Mater Res 1998; 43: 36573.
  • 2
    Brinker W, Permattei D, Flo G. Handbook of small animal orthopedics and fracture treatment. Philadelphia: WB Saunders Company; 1990. p. 53435.
  • 3
    Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 2001; 11: S3743.
  • 4
    Cook SD, Rueger DC. Osteogenic protein-1: biology and applications. Clin Orthop Rel Res 1996; 324: 2938.
  • 5
    European-Agency-for-the-Evaluation-of-Medicinal-Products: Cp-mp/0393/01, 2001. Available:
  • 6
    Fischgrund JS, James SB, Chabot MC, Hankin R, Herkowitz HN, Wozney JM, et al. Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model. J Spinal Disord 1997; 10: 46772.
  • 7
    Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions—a prospective, randomized clinical trial comparing rhOP-1 with fresh bone autograft. J Bone Joint Surg-Am 2001; 83A: S1518.
  • 8
    Hecht BP, Fischgrund JS, Herkowitz HN, Penman L, Toth JM, Shirkhoda A. The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model. Spine 2000; 25: 107S14S.
  • 9
    Hollinger J, Schmitt J, Buck D, Shannon R, Joh S, Zegzula H, et al. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration. J Biomed Mater Res 1998; 43: 35664.
  • 10
    Hollinger JO, Kleinschmidt JC. The critical size defect as an experimental model to test bone repair materials. J Craniofac Surg 1990; 1: 608.
  • 11
    Isobe M, Yamazaki Y, Mori M, Amagasa T. Bone regeneration produced in rat femur defects by polymer capsules containing recombinant human bone morphogenetic protein-2. J Oral Max-illofac Surg 1999; 57: 6958.
  • 12
    Isobe M, Yamazaki Y, Mori M, Ishihara K, Nakabayashi N, Amagasa T. The role of recombinant human bone morphogenetic protein-2 in plga capsules at an extraskeletal site of the rat. J Biomed Mater Res 1999; 45: 3641.
  • 13
    Kandziora F, Bail H, Schmidmaier G, Schollmeier G, Scholz M, Knispel C, et al. Bone morphogenetic protein-2 application by a poly(D,L-lactide)-coated interbody cage: in vivo results of a new carrier for growth factors. J Neurosurg 2002; 97: 408.
  • 14
    Kenley R, Marden L, Turek T, Jin L, Ron E, Hollinger JO. Osseous regeneration in the rat calvarium using novel delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2). J Biomed Mater Res 1994; 28: 113947.
  • 15
    Magin MN, Delling G. Improved lumbar vertebral interbody fusion using rhOP-1—a comparison of autogenous bone graft, bovine hydroxylapatite (Bio-Oss), and BMP-7 (rhOP-1) in sheep. Spine 2001; 26: 46978.
  • 16
    Marden LJ, Hollinger JO, Chaudhari A, Turek T, Schaub RG, Ron E. Recombinant human bone morphogenetic protein-2 is superior to demineralized bone-matrix in repairing craniotomy defects in rats. J Biomed Mater Res 1994; 28: 112738.
  • 17
    Mayer M, Hollinger J, Ron E, Wozney J. Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier. Plast Reconstr Surg 1996; 98: 24759.
  • 18
    Michal U, Flueckiger M, Schmoekel H. Healing of dorsal pancarpal arthrodesis in the dog. J Small Anim Pract 2003; 44: 10912.
  • 19
    Muller R, Van Campenhout H, Van Damme B, Van Der Perre G, Dequeker J, Hildebrand T, et al. Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. Bone 1998; 23: 5966.
  • 20
    Murphy G, Gavrilovic J. Proteolysis and cell migration: creating a path? Curr Opin Cell Biol 1999; 11: 61421.
  • 21
    Reddi AH. Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside. Biochem Soc Trans 2000; 28: 3459.
  • 22
    Ripamonti U, Ramoshebi LN, Matsaba T, Tasker J, Crooks J, Teare J. Bone induction by BMPs/OPs and related family members in primates—the critical role of delivery systems. J Bone Joint Surg-Am 2001; 83A: S11627.
  • 23
    Ruppert R, Hoffmann E, Sebald W. Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity. Eur J Biochem 1996; 237: 295302.
  • 24
    Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, et al. Bovine osteogenic protein is composed of dimers of op-1 and BMP-2a, two members of the transforming growth factor-beta superfamily. J Biol Chem 1990; 265: 13198205.
  • 25
    Schense JC, Bloch J, Aebischer P, Hubbell JA. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension. Nat Biotechnol 2000; 18: 4159.
  • 26
    Sieron AL, Louneva N, Fertala A. Site-specific interaction of bone morphogenetic protein 2 with procollagen II. Cytokine 2002; 18: 21421.
  • 27
    Weber F, Eyrich G, Gratz K, Thomas R, Maly F, Sailer H. Disulfide bridge conformers of mature BMP are inhibitors for heterotopic ossification. Biochem Biophys Res Commun 2001; 286: 5548.
  • 28
    Weber FE, Eyrich G, Gratz KW, Maly FE, Sailer HF. Slow and continuous application of human recombinant bone morphogenetic protein via biodegradable poly(lactide-co-glycolide) foamspheres. Int J Oral Maxillofac Surg 2002; 31: 605.
  • 29
    Woo BH, Fink BF, Page R, Schrier JA, Jo YW, Jiang G, et al. Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix. Pharm Res 2001; 18: 174753.
  • 30
    Wozney JM. The potential role of bone morphogenetic proteins in periodontal reconstruction. J Periodont 1995; 66: 50610.
  • 31
    Wozney JM. Overview of bone morphogenetic proteins. Spine 2002; 27: S28.
  • 32
    Zhu G, Mallery SR, Schwendeman SP. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide). Nat Biotechnol 2000; 18: 527.