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Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracis

  1. Vladimir A Karginov1,*,
  2. Tanisha M Robinson1,
  3. Jenny Riemenschneider2,
  4. Basil Golding2,
  5. Michael Kennedy2,
  6. Joseph Shiloach3,
  7. Ken Alibek1,4

Article first published online: 9 JAN 2006

DOI: 10.1016/S0928-8244(03)00302-X

Issue

FEMS Immunology & Medical Microbiology

FEMS Immunology & Medical Microbiology

Volume 40, Issue 1, pages 71–74, January 2004

Additional Information

How to Cite

Karginov, V. A., Robinson, T. M., Riemenschneider, J., Golding, B., Kennedy, M., Shiloach, J. and Alibek, K. (2004), Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracis. FEMS Immunology & Medical Microbiology, 40: 71–74. doi: 10.1016/S0928-8244(03)00302-X

Author Information

  1. 1

    Advanced Biosystems, Inc., 10900 University Blvd., Manassas, VA 20110, USA

  2. 2

    CBER, FDA, Bethesda, MD, USA

  3. 3

    NIDDK, NIH, Bethesda, MD, USA

  4. 4

    Center for Biodefense, George Mason University, Manassas, VA, USA

* *Corresponding author. Fax: +1 (703) 993–8447, E-mail address: vladimir.karginov@analex.com

Publication History

  1. Issue published online: 9 JAN 2006
  2. Article first published online: 9 JAN 2006
  3. Received 2 July 2003, Revised 23 September 2003, Accepted 23 September 2003

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Keywords:

  • Anthrax treatment;
  • Anti-protective antigen antibody;
  • Ciprofloxacin;
  • Mouse model

Abstract

Currently there is no effective treatment for inhalational anthrax beyond administration of antibiotics shortly after exposure. There is need for new, safe and effective treatments to supplement traditional antibiotic therapy. Our study was based on the premise that simultaneous inhibition of lethal toxin action with antibodies and blocking of bacterial growth by antibiotics will be beneficial for the treatment of anthrax. In this study, we tested the effects of a combination treatment using purified rabbit or sheep anti-protective antigen (PA) antibodies and the antibiotic ciprofloxacin in a rodent anthrax model. In mice infected with a dose of Bacillus anthracis Sterne strain corresponding to 10 LD50, antibiotic treatment with ciprofloxacin alone only cured 50% of infected animals. Administration of anti-PA IgG in combination with ciprofloxacin produced 90–100% survival. These data indicate that a combination of antibiotic/immunoglobulin therapy is more effective than antibiotic treatment alone in a rodent anthrax model.

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