The profession of midwifery can be part of the solution in America's quest for a culturally sensitive and competent health care system. Midwives who are familiar with a variety of health-related cultural beliefs and practice culturally sensitive inquiry, particularly when using pharmaceutical therapies, can effectively understand and respond to the cultural complexities that impact a client's health. This article describes needed cultural competencies, reviews a variety of health-related cultural beliefs, and relates how these beliefs impact the use and acceptability of pharmaceutical therapies. Specific examples related to culturally sensitive inquiry are discussed along with recommendations.