In a primary care setting, midwives collaboratively manage common lower respiratory conditions that require pharmacologic therapy. Current knowledge about the indications, use, adverse effects, and potential side effects of these medications is essential. This article reviews the drugs most frequently used for the outpatient treatment of asthma, tuberculosis, pneumonia, and bronchitis (acute and chronic) in adults. Recommendations from the Centers for Disease Control and Prevention guidelines and professional societies are presented. Drug pharmacology and adverse effects are discussed in detail.