This article examines the evidence on use of nutriceuticals for promotion of cardiovascular health in women. Studies elucidating mechanism of action, physiologic effects of antioxidant vitamins, carotenoids, flavonoids, and garlic are presented. Emerging evidence for the impact of homocysteine on cardiovascular risk factors and events and evidence for the impact of different types of fats on cardiovascular markers are reviewed. The effects of a heart-healthy diet are supported in this review of research on nutriceuticals. Primary prevention of cardiovascular disease in women is clearly efficacious, and this article summarizes information to be shared with women about nutriceuticals and diet to better enable decisions they can adopt to promote cardiovascular health.