Patricia Aikins Murphy received her midwifery education and Master's in Nursing from Columbia University, New York, and her Doctorate in Public Health from the Columbia University School of Public Health. She is an Associate Research Scientist in the Department of Obstetrics and Gynecology at Columbia University, where she is engaged in research, education, and clinical practice, with a current focus on contraception and women's health. She is also the director of the Clinical Core at the Columbia University Center for Complementary and Alternative Medicine Research in Women's Health.
ST. JOHN'S WORT AND ORAL CONTRACEPTIVES: REASONS FOR CONCERN?
Version of Record online: 31 DEC 2010
2002 American College of Nurse Midwives
Journal of Midwifery & Womens Health
Volume 47, Issue 6, pages 447–450, November-December 2002
How to Cite
Murphy, P. A. (2002), ST. JOHN'S WORT AND ORAL CONTRACEPTIVES: REASONS FOR CONCERN?. Journal of Midwifery & Womens Health, 47: 447–450. doi: 10.1016/S1526-9523(02)00321-5
- Issue online: 31 DEC 2010
- Version of Record online: 31 DEC 2010
St. John's wort (Hypericum perforatum) is one of the best-selling herbal remedies in the United States. It has been implicated as an inducer of the P450 enzyme system, and as such, may cause increased metabolism of certain drugs, including oral contraceptives. Women using oral contraceptives have been warned against using St. John's wort. To date, there are some case reports but little clinical data demonstrating risk of contraceptive failure if they do. This article reviews available data and discusses theoretical reasons for concern about possible drug-herb interactions.