Dept. of Molecular Biology, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland.
Multiple roles of Condensins: a complex story
Article first published online: 16 JAN 2012
2004 Société Française des Microscopies and Société Biologie Cellulaire de France
Biology of the Cell
Volume 96, Issue 3, pages 201–213, April 2004
How to Cite
Legagneux, V., Cubizolles, F. and Watrin, E. (2004), Multiple roles of Condensins: a complex story. Biology of the Cell, 96: 201–213. doi: 10.1016/j.biolcel.2004.01.003
- Issue published online: 16 JAN 2012
- Article first published online: 16 JAN 2012
- Received 16 January 2004; accepted 20 January 2004
- Cited By
- Cell division;
- Chromosomal proteins;
- Topoisomerase II
Summry— Condensins are pentameric complexes that were initially described as being involved in the dynamics of chromosomes during mitosis. It has been recently established that two related complexes (Condensin I and Condensin II) contribute to this process. An increasing sum of studies, using different approaches in various organisms, leads to the paradigm that Condensins are required for the correct segregation of replicated chromosomes by cooperating somehow with Topoisomerase II in sister chromatid resolution. Depending on species and/or experimental studies, these complexes also contribute to some aspects of the assembly and compaction of mitotic chromosomes. Recent studies provided evidences that Condensins and related complexes also function in non-mitotic processes such as replication and transcription. Biochemical studies have highlighted mechanistic aspects of Condensin function and initiated a fine functional dissection of core and regulatory subunits. However, the exact contribution of each subunit remains largely elusive as well as the functional interplay between Condensin I and Condensin II.