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Post-transcriptional regulation in cancer
Article first published online: 16 JAN 2012
2004 Société Française des Microscopies and Société Biologie Cellulaire de France
Biology of the Cell
Volume 96, Issue 7, pages 479–498, September 2004
How to Cite
Audic, Y. and Hartley, R. S. (2004), Post-transcriptional regulation in cancer. Biology of the Cell, 96: 479–498. doi: 10.1016/j.biolcel.2004.05.002
- Issue published online: 16 JAN 2012
- Article first published online: 16 JAN 2012
- Received 16 March 2004; accepted 19 May 2004
- Cited By
- RNA binding proteins
Summry— Deregulation of gene expression is a hallmark of the cancer cell. Acquiring a new profile of expressed proteins may enable the cell to re-enter the cell cycle, or give them a growth or motility advantage over “normal cells”. An efficient and rapid way to alter gene expression is via regulation of mRNAs already transcribed. Modifications of mRNA stability and/or translational efficiency are increasingly reported in cancer. mRNA stability and translation are controlled through a complex network of RNA/protein interactions involving recognition of specific target mRNAs by RNA-BPs. We review how alterations in regulatory sequences, RNA-BPs, or in upstream signalling pathways affect the stability and/or translational efficiency of mRNAs encoding proto-oncogenes, cytokines, cell cycle regulators and other regulatory proteins to promote tumorigenesis and cancer progression.
A more thorough understanding of post-transcriptional mechanisms such as these will enable the design and development of specific therapies based on modulating the translation or stability of specific mRNAs.