Potential role of centrioles in determining the morphogenetic status of animal somatic cells
Version of Record online: 2 JAN 2013
© The Author(s) Journal compilation © 2005 International Federation for Cell Biology
Cell Biology International
Volume 29, Issue 5, pages 370–374, May 2005
How to Cite
Tkemaladze, J. and Chichinadze, K. (2005), Potential role of centrioles in determining the morphogenetic status of animal somatic cells. Cell Biology International, 29: 370–374. doi: 10.1016/j.cellbi.2005.03.003
- Issue online: 2 JAN 2013
- Version of Record online: 2 JAN 2013
- Received 8 January 2005; accepted 17 February 2005
Irreversible differentiation (change of morphogenetic status) and programmed death (apoptosis) are observed only in somatic cells. Cell division is the only way by which the morphogenetic status of the offspring cells may be modified. It is known that there is a fixed limit to the number of possible cell divisions, the so-called ‘Hayflick limit’.
Existing links between cell division, differentiation and apoptosis make it possible to conclude that all these processes could be controlled by a single self-reproducing structure. Potential candidates for this replicable structure in a somatic cell are chromosomes, mitochondria (both contain DNA), and centrioles.
Centrioles (diplosome) are the most likely unit that can fully regulate the processes of irreversible differentiation, determination and modification of the morphogenetic status. It may contain differently encoded RNA molecules stacked in a definite order. During mitosis, these RNA molecules are released one by one into the cytoplasm. In the presence of reverse transcriptase and endonuclease, RNA can be embedded in nuclear DNA. This process presumably changes the status of repressed and potentially active genes and, subsequently, the morphogenetic status of a cell.