Design of compliance chamber and after-load in apparatus for cultured endothelial cells subjected to stresses


Corresponding author. Biomechanics & Medical Information Institute, Beijing University of Technology, No. 100 PingLeYuan, Beijing 100022, China. Tel.: +86 10 67391685.


In order to create a hemodynamic environment that can simulate the physiological condition of arteries, an in vitro experiment apparatus was designed whose key modules were compliance chamber and after-load. These two modules were developed based on the theories of hemodynamics. Both the normal and shear stress to which endothelial cells are exposed can be controlled with these modules, thus facilitating the research of endothelial cells subjected to stresses.