Cellular and extracellular behavior in the gerbil (Meriones unguiculatus) ventral prostate following different types of castration and the consequences of testosterone replacement

Authors

  • Sérgio Marcelino Oliveira,

    1. Department of Cell Biology, IB/UNICAMP, P.O. Box 190, Campinas 13084-971, SP, Brazil
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  • Patricia Simone Leite Vilamaior,

    1. Rio Preto Universitary Center, UNIRP, Biological Sciences School, São José do Rio Preto, SP, Brazil
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  • Lara Silvia Corradi,

    1. Department of Cell Biology, IB/UNICAMP, P.O. Box 190, Campinas 13084-971, SP, Brazil
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  • Rejane Maira Góes,

    1. Department of Cell Biology, IB/UNICAMP, P.O. Box 190, Campinas 13084-971, SP, Brazil
    2. Department of Biology, São Paulo State University, UNESP/IBILCE, Rua Cristóvão Colombo 2265, São José do Rio Preto 15054-000, SP, Brazil
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  • Sebastião Roberto Taboga

    Corresponding author
    1. Department of Cell Biology, IB/UNICAMP, P.O. Box 190, Campinas 13084-971, SP, Brazil
    2. Department of Biology, São Paulo State University, UNESP/IBILCE, Rua Cristóvão Colombo 2265, São José do Rio Preto 15054-000, SP, Brazil
      Corresponding author. Department of Biology, São Paulo State University, UNESP/IBILCE, Rua Cristóvão Colombo 2265, São José do Rio Preto 15054-000, SP, Brazil. Tel.: +55 17 3221 2386; fax: +55 17 3221 2390. taboga@ibilce.unesp.br
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Corresponding author. Department of Biology, São Paulo State University, UNESP/IBILCE, Rua Cristóvão Colombo 2265, São José do Rio Preto 15054-000, SP, Brazil. Tel.: +55 17 3221 2386; fax: +55 17 3221 2390. taboga@ibilce.unesp.br

Abstract

Mongolian gerbils (Meriones unguiculatus) were grouped into two experimental groups: GEx.01 suffered orchiectomy and after 30 days received doses of testosterone cipionate (T), while GEx.02 received weekly and alternated doses of the anti-androgens cyproterone acetate and flutamide for 30 days, and the animals were then euthanized. Structural evaluation reveals a more intense reduction in epithelial height in GEx.02. Smooth muscle cells (SMC) presented a star-shaped aspect after 30 days of hormonal ablation and basal membrane was shown to be more intensely grooved in GEx.01. In both groups, after hormonal replacement, recovery in epithelial height could be noted and the SMC presented its phenotypes, but an increase in RER was seen, characterizing a modulation from its contractile to secreting phenotype. In conclusion, the prostate presented involution capacity after androgen ablation and the ability to reorganize after hormonal replacement, but events resulting from orchiectomy and subsequent T replacement were shown to be more aggressive to the prostate.

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