Human SIRT1: A potential biomarker for tumorigenesis?
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 2007 International Federation for Cell Biology
Cell Biology International
Volume 31, Issue 6, pages 636–637, June 2007
How to Cite
Lim, C.-S. (2007), Human SIRT1: A potential biomarker for tumorigenesis?. Cell Biology International, 31: 636–637. doi: 10.1016/j.cellbi.2006.11.003
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Received 13 April 2006; accepted 6 November 2006
Accumulating body of evidence reveals that hSIRT1, an NAD+-dependent protein deacetylase, is involved in regulating numerous biological processes. Therefore cellular functions of hSIRT1 are highly pleiotropic. The integrated hypothetical mechanisms of hSIRT1 action contributing to regulating cellular senescence and longevity have been proposed. Based on recent evidence, I propose that hSIRT1 is a potential biomarker for tumorigenesis.