Former address: University of Wisconsin Medical School and William S. Middleton Memorial Veteran Hospital, Madison, WI 53705, USA. Tel.: +1 608 256 1901x17818.
Expression of KIT receptor tyrosine kinase protein in normal human skin: Preliminary observations
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 2007 International Federation for Cell Biology
Cell Biology International
Volume 31, Issue 7, pages 748–751, July 2007
How to Cite
Hussein, M. R. (2007), Expression of KIT receptor tyrosine kinase protein in normal human skin: Preliminary observations. Cell Biology International, 31: 748–751. doi: 10.1016/j.cellbi.2006.12.006
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Received 28 October 2006; revised 1 December 2006; accepted 15 December 2006
KIT proto-oncogene is a receptor tyrosine kinase critical for signal transduction in several cell types. An understanding of KIT distribution in normal skin may reveal new insights into its implication in cutaneous biology and its associated disease states. This study examines expression patterns of KIT protein in normal human skin. KIT protein expression was examined in 50 specimens of normal human skin using specific antibodies (CD117) and immunoperoxidase staining methods. KIT protein expression was seen in keratinocytes (stratum basale), melanocytes, mast cells, and in both sebaceous and sweat glands. In contrast, KIT protein expression was absent in stratum spinosum, stratum granulosum, stratum corneum, blood vessels and arrector pili muscle. Thus, the expression of KIT protein in normal human skin suggests its possible role in regulation of cutaneous development and function.