Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 2007 International Federation for Cell Biology
Cell Biology International
Volume 31, Issue 10, pages 1191–1197, October 2007
How to Cite
Otaki, S., Ueshima, S., Shiraishi, K., Sugiyama, K., Hamada, S., Yorimoto, M. and Matsuo, O. (2007), Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice. Cell Biology International, 31: 1191–1197. doi: 10.1016/j.cellbi.2007.04.001
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Received 27 December 2006; revised 19 March 2007; accepted 3 April 2007
- Dental pulp;
- Mesenchymal progenitor cell;
- Bone formation
The technique of tissue engineering is developing for the restoration of lost tissues. This new technique requires cells that fabricate tissue. Mesenchymal stem cells in bone marrow have been used as the cell source for this technique; however, dental pulp cells have recently been shown to possess stem-cell-like properties.
We earlier demonstrated that dental pulp cells proliferate and produce an extracellular matrix that subsequently becomes mineralized in vitro. We now report that such dental pulp cells (first to eighth passage) produced bone instead of dentin when those cells were implanted into subcutaneous sites in immunocompromised mice with HA/TCP powder as their carrier. This evidence shows that dental pulp cells are the common progenitors of odontoblasts and osteoblasts, or dental pulp cells are mesenchymal stem cells themselves.
It is expected that dental pulp cells can be a useful candidate cell source for tissue engineering, and contain the potential of new therapeutic approaches for the restoration of damaged or diseased tissue.