Histamine H4 receptor expression is elevated in human nasal polyp tissue

Authors

  • Adrienn Jókúti,

    1. Department of Otorhinolaryngology—Bajcsy-Zsilinszky Hospital, Maglódi út 89-91, H-1106 Budapest, Hungary
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    • Tel.: +36 20 315 9055.

  • Éva Hellinger,

    1. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary
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  • Andrea Hellinger,

    1. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary
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  • Zsuzsa Darvas,

    1. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary
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  • András Falus,

    Corresponding author
    1. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary
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  • Robin L. Thurmond,

    1. Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Road, San Diego, CA 92121, United States
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    • Tel.: +1 (858) 784 3108; fax: +1 (858) 450 2081.

  • Andor Hirschberg

    1. Department of Otorhinolaryngology—Saint John Hospital, Diós árok l-3, H-1125 Budapest, Hungary
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    • Tel.:+36 30 942 4964; fax: +36 1 458 4597.


Corresponding author. Tel.: +36 1 210 2929; fax: +36 1 303 6968. jokutia@yahoo.com, faland@dgci.sote.hu, rthurmon@prdus.jnj.com, hirschberg@t-online.hu

Abstract

Altered histamine metabolism is thought to be involved in the pathomechanism of nasal polyposis characterized by local eosinophil infiltration. The present study was performed to determine whether histamine receptors play a role in the effect of histamine in nasal polyp tissue. The findings suggest that the expression of H1 and H4 receptors is elevated in polyp tissue (p = 0.045; p < 0.001), while the level of H2 and H3 receptors is not increased significantly. The elevation of H1 and H4 receptors' expression may indicate that the histamine related mechanisms are preferentially mediated through H1 and H4 histamine receptors in the polyp tissue. Simultaneously with increased H4 receptor expression, the concentration of eosinophil cationic protein (ECP) was increased significantly in polyp tissue (p = 0.002). One may speculate that the H4 receptor mediated histamine effects have a role in eosinophil accumulation and activation in inflammatory diseases of the nasal and paranasal sinus mucosa, such as nasal polyposis.

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