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Histamine H4 receptor expression is elevated in human nasal polyp tissue
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 2007 International Federation for Cell Biology
Cell Biology International
Volume 31, Issue 11, pages 1367–1370, November 2007
How to Cite
Jókúti, A., Hellinger, É., Hellinger, A., Darvas, Z., Falus, A., Thurmond, R. L. and Hirschberg, A. (2007), Histamine H4 receptor expression is elevated in human nasal polyp tissue. Cell Biology International, 31: 1367–1370. doi: 10.1016/j.cellbi.2007.05.011
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Received 30 December 2006; revised 9 April 2007; accepted 12 May 2007
- Eosinophil cationic protein;
- H4 receptor;
- Nasal polyp
Altered histamine metabolism is thought to be involved in the pathomechanism of nasal polyposis characterized by local eosinophil infiltration. The present study was performed to determine whether histamine receptors play a role in the effect of histamine in nasal polyp tissue. The findings suggest that the expression of H1 and H4 receptors is elevated in polyp tissue (p = 0.045; p < 0.001), while the level of H2 and H3 receptors is not increased significantly. The elevation of H1 and H4 receptors' expression may indicate that the histamine related mechanisms are preferentially mediated through H1 and H4 histamine receptors in the polyp tissue. Simultaneously with increased H4 receptor expression, the concentration of eosinophil cationic protein (ECP) was increased significantly in polyp tissue (p = 0.002). One may speculate that the H4 receptor mediated histamine effects have a role in eosinophil accumulation and activation in inflammatory diseases of the nasal and paranasal sinus mucosa, such as nasal polyposis.