Tumour necrosis factor-α receptor 1 polymorphisms and serum soluble TNFR1 in early spontaneous miscarriage
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 2007 International Federation for Cell Biology
Cell Biology International
Volume 31, Issue 11, pages 1396–1399, November 2007
How to Cite
Yu, X.-W., Li, X., Ren, Y.-H. and Li, X.-C. (2007), Tumour necrosis factor-α receptor 1 polymorphisms and serum soluble TNFR1 in early spontaneous miscarriage. Cell Biology International, 31: 1396–1399. doi: 10.1016/j.cellbi.2007.06.005
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Received 9 May 2007; revised 3 June 2007; accepted 6 June 2007
- Early recurrent spontaneous miscarriage (ERSM);
- Tumour necrosis factor receptor 1 (TNFR1);
- Soluble TNFR1(sTNFR1);
- Gene polymorphism;
- Single nucleotide polymorphisms (SNPs)
Objectives: The study investigated the association of TNFR1 gene polymorphism with early recurrent spontaneous miscarriage (ERSM) in Chinese women, and soluble TNFR1 (sTNFR1) expression in ERSM women.
Study design: Two single nucleotide polymorphisms (SNPs) located at −383 (AGA to AGC) in the promoter region and +36 (CCA to CCG) in exon 1 of TNFR1 were investigated in 188 non-pregnant ERSM Chinese women. The serum sTNFR1 was measured by the ELISA method.
Results: Both SNPs were not associated with ERSM. The non-pregnant ERSM women had significantly higher levels of serum sTNFR1, compared with the non-pregnant, normal women (1.84 ± 0.54 ng/ml versus 1.62 ± 0.38 ng/ml; t = −2.053; p < 0.05).
Conclusions: The data do not provide evidence that TNFR1 gene polymorphism is etiologically important for ERSM in Chinese women. But, a significantly raised sTNFR1 level in non-pregnant ERSM women was recorded compared to women with normal pregnancies. The result suggests that pregnancy failure is associated with an increase of sTNFR1.