Immunohistological evaluation of immune cell infiltrate in cutaneous Kaposi's sarcoma

Authors

  • Mahmoud R. Hussein

    Corresponding author
    1. Department of Pathology, Assiut University Hospitals, Faculty of Medicine, Assiut University, Assiut, Egypt
      Tel.: +2 093 2581258; fax: +2 088 332278. mrcpath17@gmail.com mrh17@gawab.com
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Tel.: +2 093 2581258; fax: +2 088 332278. mrcpath17@gmail.com mrh17@gawab.com

Abstract

Typically, Kaposi's sarcoma (KS) also presents with immune cell infiltrates. This study does immunophenotype characterization for demographics of some of these cells to test the hypothesis that ‘development of end-stage (nodular/tumor) KS is associated with numeric alteration in immune cell infiltrates.’ Fifteen cases of classic-KS (nodular/tumor) and 20 normal biopsies were examined using antigen-antibody reactions and immunoperoxidase staining for histiocytes (CD68), B cells (CD20) and T cells (CD3). Variations between normal and lesions were observed with significant increases in immune cell infiltrates (2.3 ± 0.6 vs. 6.4 ± 0.4); CD68+ (4.0 ± 1.0 vs. 7.0 ± 0.5); CD3+ (3.0 ± 1.1 vs. 10.1 ± 0.8); and CD20+ (0.0 ± 0.0 vs. 0.3 ± 0.0). Increased density of immune cells in the nodular lesions of KS may reflect increased antigenicity of these lesions; the increase in T cells suggests enhanced T cell activity in KS. However, these issues should be tested by further studies.

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