The two authors contributed equally to this work.
17β-Estradiol affects proliferation and apoptosis of rat prostatic smooth muscle cells by modulating cell cycle transition and related proteins
Article first published online: 2 JAN 2013
© The Author(s) Journal compilation © 2008 International Federation for Cell Biology
Cell Biology International
Volume 32, Issue 8, pages 899–905, August 2008
How to Cite
Luo, Y., Waladali, W., Li, S., Zheng, X., Hu, L., Zheng, H., Hu, W. and Chen, C. (2008), 17β-Estradiol affects proliferation and apoptosis of rat prostatic smooth muscle cells by modulating cell cycle transition and related proteins. Cell Biology International, 32: 899–905. doi: 10.1016/j.cellbi.2008.03.023
- Issue published online: 2 JAN 2013
- Article first published online: 2 JAN 2013
- Received 16 December 2007, revised 4 February 2008, accepted 28 March 2008
- Smooth muscle cell;
- Cell cycle
Abundant evidence indicates that estrogens have an important role in the pathology of benign prostatic hyperplasia (BPH). To investigate the effect of 17β-estradiol (E2) on the proliferation and apoptosis of prostatic smooth muscle cells (PSMCs), rat PSMCs were obtained and exposed to gradient concentrations (0.1–100 nmol/l) of E2 over varying amounts of time. The progression of cell cycle, cellular apoptosis, cyclin D1, Bcl-2 and Bax proteins were detected. The data show that the effect of E2 on rat PSMCs is bilateral: it promotes cell proliferation by enhancing the expression of cyclin D1, which accelerates G 1 to S phase transition; on the other hand, it induces apoptosis of the cells by up-regulating the expression of Bax. We thus suggest that an increase in estrogen may exert a launching effect in the pathology of BPH.