Licochalcone A inhibits the formation and bone resorptive activity of osteoclasts

Authors

  • Soon Nam Kim,

    1. Laboratory of Chemical Genomics, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea
    2. Department of Biology, Chungnam National University, Daejeon 305-764, Republic of Korea
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  • Myung Hee Kim,

    1. Laboratory of Chemical Genomics, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea
    2. Department of Biochemistry, Chungnam National University, Daejeon 305-764, Republic of Korea
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  • Yong Ki Min,

    1. Laboratory of Chemical Genomics, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea
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  • Seong Hwan Kim

    Corresponding author
    1. Laboratory of Chemical Genomics, Korea Research Institute of Chemical Technology, P.O. Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea
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Corresponding author. Tel.: +82 42 860 7687; fax: +82 42 861 0307. hwan@krict.re.kr

Abstract

Licochalcone A on the formation and bone resorptive activity of osteoclasts up to 5 μM significantly inhibited the receptor activator of nuclear factor κB (NF-κB) ligand (RANKL)-induced activity of tartrate-resistant acid phosphatase (TRAP) activity and formation of osteoclasts without any effect on cell viability. Interestingly, licochalcone A was shown to inhibit the RANKL-induced activation of extracellular signal-regulated kinase, translocation of NF-κB into nucleus and mRNA expression of Fra-2. Licochalcone A also inhibited the bone resorptive activity of mature osteoclasts and the expression of bone resorption-related genes. Inhibitory effects of licochalcone A on the formation and bone resorptive activity of mouse bone marrow macrophage-derived osteoclasts were also observed. In conclusion, licochalcone A has the potential to inhibit the formation of osteoclasts as well as the bone resorptive activity of mature osteoclasts.

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