Get access

TNF superfamily: Costimulation and clinical applications

Authors

  • Dass S. Vinay,

    1. Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA
    Search for more papers by this author
  • Byoung S. Kwon

    Corresponding author
    1. Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA
    2. Cell and Immunobiology and R&D Center for Cancer Therapeutics, National Cancer Center, Ilsan, Gyeonggi-Do, Republic of Korea
    Search for more papers by this author

Cell and Immunobiology and R&D Center for Cancer Therapeutics, National Cancer Center, 111 Jungbalsan-Ro, Ilsan, Goyang, Gyeonggi-Do 410-769, Republic of Korea. Tel.: +82 31 920 2531; fax: +82 31 920 2542. E-mail addresses: bskwon@ncc.re.kr

Abstract

The molecules concerned with costimulation belong either to the immunoglobulin (Ig) or tumor necrosis factor (TNF) superfamily. The tumor necrosis superfamily comprises molecules capable of providing both costimulation and cell death. In this review we briefly summarize certain TNF superfamily receptor–ligand pairs that are endowed with costimulatory properties and their importance in health and disease.

Ancillary