Circulating Stromelysin-1 (MMP-3): A novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction
Article first published online: 13 JAN 2014
Published on behalf of the European Society of Cardiology. All rights reserved. © 2008 the Authors
European Journal of Heart Failure
Volume 10, Issue 2, pages 133–139, February 2008
How to Cite
Kelly, D., Khan, S., Cockerill, G., Ng, L.L., Thompson, M., Samani, N.J. and Squire, I.B. (2008), Circulating Stromelysin-1 (MMP-3): A novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction. European Journal of Heart Failure, 10: 133–139. doi: 10.1016/j.ejheart.2007.12.009
- Issue published online: 13 JAN 2014
- Article first published online: 13 JAN 2014
- Manuscript Accepted: 5 DEC 2007
- Manuscript Revised: 20 OCT 2007
- Manuscript Received: 11 JUL 2007
- Matrix metalloproteinase;
- Heart failure;
- Acute myocardial infarction
Changes to cardiac matrix are central to ventricular remodelling after acute MI and matrix metalloproteinase expression is implicated in this process. We investigated the temporal profile of MMP-3 and its relationship to LV dysfunction and prognosis following AMI.
We studied 382 patients with AMI. Plasma MMP-3 was measured at 0–12, 12–24 h and for subsequent 24 h periods during admission. LV function (LVEF) was assessed by echocardiography pre-discharge and at a median of 148 days and clinical endpoints at a median of 313 days.
MMP-3 peaked prior to discharge thus pre-discharge levels were used in analyses. MMP-3 was associated with patient age (p<0.001), creatinine (p<0.001) and was higher in males (p<0.001) and hypertensives (p<0.001). MMP-3 inversely correlated with LVEF at follow-up (p=0.043), was higher in subjects with LVEF <40% (p=0.017) and in subjects with increasing EDV (p=0.017) or ESV (p=0.007) compared to those in whom volumes fell between visits. In the 58 patients reaching the endpoint of death or heart failure, MMP-3 was higher (p<0.001). On Kaplan–Meier analysis, subjects with levels above optimum cut off identified via ROC curves were more likely to suffer a clinical event (p=0.037).
MMP-3 is associated with left ventricular dysfunction, adverse left ventricular remodelling and prognosis after AMI.