Functional Foods Forum, The University of Turku, Itäinen Pitkäkatu 4A, 5th floor, Fin-20520 Turku, Finland.
Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota
Article first published online: 9 JAN 2006
FEMS Immunology & Medical Microbiology
Volume 43, Issue 1, pages 59–65, January 2005
How to Cite
Rinne, M. M., Gueimonde, M., Kalliomäki, M., Hoppu, U., Salminen, S. J. and Isolauri, E. (2005), Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota. FEMS Immunology & Medical Microbiology, 43: 59–65. doi: 10.1016/j.femsim.2004.07.005
Sources of support: the Academy of Finland (MICMAN), Turku University Central Hospital Research Funds.
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 3 May 2004, Revised 8 July 2004, Accepted 9 July 2004
- Gut microbiota;
The aim of the study was to assess the quantitative and qualitative differences of the gut microbiota in infants. We evaluated gut microbiota at the age of 6 months in 32 infants who were either exclusively breast-fed, formula-fed, nursed by a formula supplemented with prebiotics (a mixture of fructo- and galacto-oligosaccharides) or breast-fed by mothers who had been given probiotics. The Bifidobacterium, Bacteroides, Clostridium and Lactobacillus/Enterococcus microbiota were assessed by the fluorescence in situ hybridization, and Bifidobacterium species were further characterized by PCR. Total number of bifidobacteria was lower among the formula-fed group than in other groups (P= 0.044). Total amounts of the other bacteria were comparable between the groups. The specific Bifidobacterium microbiota composition of the breast-fed infants was achieved in infants receiving prebiotic supplemented formula. This would suggest that early gut Bifidobacterium microbiota can be modified by special diets up to the age of 6 months.