• [1]
    Medzhitov, R., Janeway, C.A., Jr (2002) Decoding the patterns of self and nonself by the innate immune system. Science 296, 298300.
  • [2]
    Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., Toda, M. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains CD25. Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 11511164.
  • [3]
    Groux, H., O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, J.E., Roncarolo, M.G. (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737742.
  • [4]
    Weiner, H.L. (2001) Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 182, 207214.
  • [5]
    Sakaguchi, S., Sakaguchi, N., Shimizu, J., Yamazaki, S., Sakihama, T., Itoh, M., Kuniyasu, Y., Nomura, T., Toda, M., Takahashi, T. (2001) Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182, 1832.
  • [6]
    Asano, M., Toda, M., Sakaguchi, N., Sakaguchi, S. (1996) Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184, 387396.
  • [7]
    Suri-Payer, E., Amar, A.Z., Thornton, A.M., Shevach, E.M. (1998) CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 160, 12121218.
  • [8]
    Jonuleit, H., Schmitt, E., Stassen, M., Tuettenberg, A., Knop, J., Enk, A.H. (2001) Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193, 12851294.
  • [9]
    Wing, K., Ekmark, A., Karlsson, H., Rudin, A., Suri-Payer, E. (2002) Characterization of human CD25+CD4+ T cells in thymus, cord and adult blood. Immunology 106, 190199.
  • [10]
    Stephens, L.A., Mottet, C., Mason, D., Powrie, F. (2001) Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 31, 12471254.
  • [11]
    Wing, K., Lindgren, S., Kollberg, G., Lundgren, A., Harris, R.A., Rudin, A., Lundin, S., Suri-Payer, E. (2003) CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells. Eur. J. Immunol. 33, 579587.
  • [12]
    Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J., Sakaguchi, S. (1998) Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10, 19691980.
  • [13]
    Ng, W.F., Duggan, P.J., Ponchel, F., Matarese, G., Lombardi, G., Edwards, A.D., Isaacs, J.D., Lechler, R.I. (2001) Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells. Blood 98, 27362744.
  • [14]
    Thornton, A.M., Shevach, E.M. (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188, 287296.
  • [15]
    Klein, L., Khazaie, K., von Boehmer, H. (2003) In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100, 88868891.
  • [16]
    Fisson, S., Darrasse-Jeze, G., Litvinova, E., Septier, F., Klatzmann, D., Liblau, R., Salomon, B.L. (2003) Continuous activation of autoreactive CD4+CD25+ regulatory T cells in the steady state. J. Exp. Med. 198, 737746.
  • [17]
    Walker, L.S., Chodos, A., Eggena, M., Dooms, H., Abbas, A.K. (2003) Antigen-dependent proliferation of CD4+CD25+ regulatory T cells in vivo. J. Exp. Med. 198, 249258.
  • [18]
    Gavin, M.A., Clarke, S.R., Negrou, E., Gallegos, A., Rudensky, A. (2002) Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo. Nat. Immunol. 3, 3341.
  • [19]
    Brunkow, M.E., Jeffery, E.W., Hjerrild, K.A., Paeper, B., Clark, L.B., Yasayko, S.A., Wilkinson, J.E., Galas, D., Ziegler, S.F., Ramsdell, F. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27, 6873.
  • [20]
    Hori, S., Nomura, T., Sakaguchi, S. (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 10571061.
  • [21]
    Apostolou, I., Von Boehmer, H. (2004) In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199, 14011408.
  • [22]
    Dieckmann, D., Bruett, C.H., Ploettner, H., Lutz, M.B., Schuler, G. (2002) Human CD4+CD25+ regulatory, contact-dependent T cells induce interleukin 1-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med. 196, 247253.
  • [23]
    Jonuleit, H., Schmitt, E., Kakirman, H., Stassen, M., Knop, J., Enk, A.H. (2002) Infectious tolerance: Human CD25+ regulatory T cells convey suppressor activity to conventional CD4+ T helper cells. J. Exp. Med. 196, 255260.
  • [24]
    Stassen, M., Fondel, S., Bopp, T., Richter, C., Muller, C., Kubach, J., Becker, C., Knop, J., Enk, A.H., Schmitt, S. et-al (2004) Human CD25+ regulatory T cells: two subsets defined by the integrins alpha4beta7 or alpha4beta1 confer distinct suppressive properties upon CD4+ T helper cells. Eur. J. Immunol. 34, 13031311.
  • [25]
    McGuirk, P., McCann, C., Mills, K.H. (2002) Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195, 221231.
  • [26]
    Hori, S., Carvalho, T.L., Demengeot, J. (2002) CD25+CD4+ regulatory T cells suppress CD4+T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur. J. Immunol. 32, 12821291.
  • [27]
    Aseffa, A., Gumy, A., Launois, P., MacDonald, H.R., Louis, J.A., Tacchini-Cottier, F. (2002) The Early IL-4 Response to Leishmania major and the Resulting Th2 Cell Maturation Steering Progressive Disease in BALB/c Mice Are Subject to the Control of Regulatory CD4+CD25+ T Cells. J. Immunol. 169, 32323241.
  • [28]
    Belkaid, Y., Piccirillo, C.A., Mendez, S., Shevach, E.M., Sacks, D.L. (2002) CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420, 502507.
  • [29]
    Kursar, M., Bonhagen, K., Fensterle, J., Kohler, A., Hurwitz, R., Kamradt, T., Kaufmann, S.H., Mittrucker, H.W. (2002) Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses. J. Exp. Med. 196, 15851592.
  • [30]
    Suvas, S., Kumaraguru, U., Pack, C.D., Lee, S., Rouse, B.T. (2003) CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J. Exp. Med. 198, 889901.
  • [31]
    Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M., Demengeot, J. (2003) Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197, 403411.
  • [32]
    Hisaeda, H., Maekawa, Y., Iwakawa, D., Okada, H., Himeno, K., Kishihara, K., Tsukumo, S., Yasutomo, K. (2004) Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells. Nat. Med. 10, 2930.
  • [33]
    Ernst, P.B., Gold, B.D. (2000) The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu. Rev. Microbiol. 54, 615640.
  • [34]
    Raghavan, S., Fredriksson, M., Svennerholm, A.M., Holmgren, J., Suri-Payer, E. (2003) Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice. Clin. Exp. Immunol. 132, 393400.
  • [35]
    Raghavan, S., Suri-Payer, E., Holmgren, J. (2004) Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4+CD25+ regulatory T cells. Scand. J. Immunol. 60, 8288.
  • [36]
    Lundgren, A., Suri-Payer, E., Enarsson, K., Svennerholm, A.M., Lundin, B.S. (2003) Helicobacter pylori-specific CD4+CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect. Immun. 71, 17551762.
  • [37]
    Garhart, C.A., Redline, R.W., Nedrud, J.G., Czinn, S.J. (2002) Clearance of Helicobacter pylori infection and resolution of postimmunization gastritis in a kinetic study of prophylactically immunized mice. Infect. Immun. 70, 35293538.
  • [38]
    Raghavan, S., Svennerholm, A.M., Holmgren, J. (2002) Effects of oral vaccination and immunomodulation by cholera toxin on experimental Helicobacter pylori infection, reinfection, and gastritis. Infect. Immun. 70, 46214627.
  • [39]
    Kullberg, M.C., Jankovic, D., Gorelick, P.L., Caspar, P., Letterio, J.J., Cheever, A.W., Sher, A. (2002) Bacteria-triggered CD4+ T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 196, 505515.
  • [40]
    Amedei, A., Bergman, M.P., Appelmelk, B.J., Azzurri, A., Benagiano, M., Tamburini, C., van der Zee, R., Telford, J.L., Vandenbroucke-Grauls, C.M., D'Elios, M.M. et-al (2003) Molecular mimicry between Helicobacter pylori antigens and H+, K+-adenosine triphosphatase in human gastric autoimmunity. J. Exp. Med. 198, 11471156.
  • [41]
    Stromberg, E., Edebo, A., Svennerholm, A.M., Lindholm, C. (2003) Decreased epithelial cytokine responses in the duodenal mucosa of Helicobacter pylori-infected duodenal ulcer patients. Clin. Diagn. Lab. Immunol. 10, 116124.
  • [42]
    Stromberg, E., Lundgren, A., Edebo, A., Lundin, S., Svennerholm, A.M., Lindholm, C. (2003) Increased frequency of activated T-cells in the Helicobacter pylori-infected antrum and duodenum. FEMS Immunol. Med. Microbiol. 36, 159168.
  • [43]
    Hamlet, A., Thoreson, A.C., Nilsson, O., Svennerholm, A.M., Olbe, L. (1999) Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers. Gastroenterology 116, 259268.