These authors contributed equally to this paper.
The role of genome diversity and immune evasion in persistent infection with Helicobacter pylori
Article first published online: 9 JAN 2006
FEMS Immunology & Medical Microbiology
Volume 45, Issue 1, pages 11–23, July 2005
How to Cite
Cooke, C. L., Huff, J. L. and Solnick, J. V. (2005), The role of genome diversity and immune evasion in persistent infection with Helicobacter pylori. FEMS Immunology & Medical Microbiology, 45: 11–23. doi: 10.1016/j.femsim.2005.04.002
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 29 March 2005, Revised 14 April 2005, Accepted 15 April 2005
- Helicobacter pylori;
- Immune evasion;
- Genome diversity
Helicobacter pylori is an important human pathogen that chronically colonizes the stomach of half the world's population. Infection typically occurs in childhood and persists for decades, if not for the lifetime of the host. How is bacterial persistence possible despite a vigorous innate and adaptive immune response? Here we describe the complex role of bacterial diversity and specific mechanisms to avoid or subvert host immunity in bacterial persistence. We suggest that H. pylori finely modulates the extent to which it interacts with the host in order to promote chronic infection, and that it uses diverse mechanisms to do so.