These authors contributed equally to this work.
ADAMs are present in fungi: Identification of two novel ADAM genes in Aspergillus fumigatus
Version of Record online: 10 JAN 2006
FEMS Microbiology Letters
Volume 248, Issue 1, pages 23–30, July 2005
How to Cite
Lavens, S. E., Rovira-Graells, N., Birch, M. and Tuckwell, D. (2005), ADAMs are present in fungi: Identification of two novel ADAM genes in Aspergillus fumigatus. FEMS Microbiology Letters, 248: 23–30. doi: 10.1016/j.femsle.2005.05.017
Edited by R. Fischer
- Issue online: 10 JAN 2006
- Version of Record online: 10 JAN 2006
- Received 12 April 2005, Revised 11 May 2005, Accepted 11 May 2005
The ADAMs are a family of integral membrane proteases involved in shedding and fusion events in animal tissues. Here, we report the identification of two ADAMs, ADM-A and ADM-B, in the pathogenic fungus Aspergillus fumigatus. The domain structure of metazoan ADAMs was seen in ADM-A and -B, although with some differences. ADAMs were identified in other filamentous fungi and phylogenetic analysis indicated that the fungal ADAMs were monophyletic and most closely related to metazoan ADAM 10 and 17. Recombinant ADM-B protease specifically cleaved casein and albumin while recombinant propeptide + protease was inactive. A sheddase function is therefore proposed for fungal ADAMs.