Moraxella catarrhalis is only a weak activator of the mannose-binding lectin (MBL) pathway of complement activation

Authors


  • Edited by M. Mitsuyama

*Corresponding author. Tel.: +31 10 4632176; fax: +31 10 4632171., E-mail address: j.hays@erasmusmc.nl

Abstract

A hemolytic bystander assay was used to assess the functional serum mannose-binding lectin (MBL) activating capacity of five isolates of Moraxella catarrhalis obtained from children who suffered recurrent acute otitis media episodes. Results showed that this organism is only a poor activator of the lectin pathway of complement activation, with subsequent consequences for the etiology of otitis media by this organism.

Ancillary