Edited by J.A. Gil
You have full text access to this OnlineOpen article
An unexpected role for the putative 4′-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in Streptomyces noursei ATCC 11455
Article first published online: 9 JAN 2006
DOI: 10.1016/j.femsle.2005.05.052
Additional Information
How to Cite
Volokhan, O., Sletta, H., Sekurova, O. N., Ellingsen, T. E. and Zotchev, S. B. (2005), An unexpected role for the putative 4′-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in Streptomyces noursei ATCC 11455. FEMS Microbiology Letters, 249: 57–64. doi: 10.1016/j.femsle.2005.05.052
Publication History
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 25 April 2005, Revised 31 May 2005, Accepted 31 May 2005
References
- [1], , , , , , (2000) Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455 analysis of the gene cluster and deduction of the biosynthetic pathway. Chem. Biol. 7, 395–403.
- [2], , , , , , (2004) Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC. Antimicrob. Agents. Chemother. 48, 4120–4129.
- [3], , , (2001) A phosphopantetheinyl transferase homolog is essential for Photorhabdus luminescens to support growth and reproduction of the entomopathogenic nematode Heterorhabditis bacteriophora. J. Bacteriol. 183, 3117–3126.
- [4]
- [5](2002) A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus. Front. Biosci. 7, 2045–2057.
- [6], , (2001) The A-factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus. J. Ind. Microbiol. Biotechnol. 27, 177–182.
- [7], , , , (1984) B-factor, an essential regulatory substance inducing the production of rifamycin in a Nocardia sp. J.Antibiot. 7, 587–1595.
- [8], , , , , , , , (1996) A new enzyme superfamily – the phosphopantetheinyl transferases. Chem. Biol. 3, 923–936.
- [9], , (2004) Chemical communication in proteobacteria: biochemical and structural studies of signal synthases and receptors required for intercellular signalling. Mol. Microbiol. 53, 755–769.
- [10], , (2004) Biosynthesis of the dichloroacetyl component of chloramphenicol in Streptomyces venezuelae ISP5230: genes required for halogenation. Microbiology 150, 85–94.
- [11], , , , , (1998) Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37, 1585–1595.
- [12], , , , (2004) PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis. J. Biol. Chem. 279, 41586–41593.
- [13]Sambrook, J., Fritsch, E.F., Maniatis, T. (1989) Molecular cloning a laboratory manual, 2nd Edn. Spring Harbor Laboratory Press, Cold Cold Spring Harbor, NY.
- [14], , , , (2001) Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC 15003 the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chem. Biol. 8, 725–738.
- [15], , , , (1999) Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC 11455. FEMS Microbiol. Lett. 177, 297–304.
- [16], , , , , , , , (2004) In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. J. Bacteriol. 186, 1345–1354.
- [17], , , , (2004) Identification and characterization of the pswP gene required for the parallel production of prodigiosin and serrawettin W1 in Serratia marcescens. Microbiol. Immunol. 48, 723–728.
- [18], , , , , , , , , (2005) A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor. Mol. Microbiol. 56, 465–479.
- [19], , , , , , , , (2002) Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic. Antimicrob. Agents Chemother. 46, 1174–1182.
- [20], , , , (1997) Post-translational modification of polyketide and nonribosomal peptide synthases. Curr. Opin. Chem. Biol. 1, 309–315.
- [21], , (2001) Cloning and functional analysis of a phosphopantetheinyl transferase superfamily gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230. Microbiology 147, 1535–1545.
- [22], , , , (2004) Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea. Chembiochem 5, 116–125.
- [23], , , , , (1999) Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis. FEMS Microbiol. Lett. 170, 381–387.
- [24], , , (1997) Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis. J. Bacteriol. 179, 7055–7062.
- [25], , , , , (2000) Identification and partial characterization of the gene cluster governing biosynthesis of a novel antibacterial polyketide-derived antibiotic in Streptomyces noursei ATCC 11455. Microbiology 146, 611–619.

1574-6968/asset/FML_left.gif?v=1&s=d9ad90a5f75253894fe5059aa2f75bf910ebf83a)
1574-6968/asset/FML_right.gif?v=1&s=48d5e33deef512c09651020f71074ad93d3351e7)
1574-6968/asset/cover.gif?v=1&s=069bb2c224e243333d4486580fbd90d9ebeffa6b)