• [1]
    Brautaset, T., Sekurova, O.N., Sletta, H., Ellingsen, T.E., Strøm, A.R., Valla, S., Zotchev, S.B. (2000) Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455 analysis of the gene cluster and deduction of the biosynthetic pathway. Chem. Biol. 7, 395403.
  • [2]
    Bruheim, P., Borgos, S.E., Tsan, P., Sletta, H., Ellingsen, T.E., Lancelin, J.M., Zotchev, S.B. (2004) Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC. Antimicrob. Agents. Chemother. 48, 41204129.
  • [3]
    Ciche, T.A., Bintrim, S.B., Horswill, A.R., Ensign, J.C. (2001) A phosphopantetheinyl transferase homolog is essential for Photorhabdus luminescens to support growth and reproduction of the entomopathogenic nematode Heterorhabditis bacteriophora. J. Bacteriol. 183, 31173126.
  • [4]
    Demain, A.L. (1998) Induction of microbial secondary metabolism. Int. Microbiol. 1, 259264.
  • [5]
    Horinouchi, S. (2002) A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus. Front. Biosci. 7, 20452057.
  • [6]
    Horinouchi, S., Ohnishi, Y., Kang, D.K. (2001) The A-factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus. J. Ind. Microbiol. Biotechnol. 27, 177182.
  • [7]
    Kawaguchi, T., Asahi, T., Satoh, T., Uozumi, T., Beppu, T. (1984) B-factor, an essential regulatory substance inducing the production of rifamycin in a Nocardia sp. J.Antibiot. 7, 5871595.
  • [8]
    Lambalot, R.H., Gehring, A.M., Flugel, R.S., Zuber, P., LaCelle, M., Marahiel, M.A., Reid, R., Khosla, C., Walsh, C.T. (1996) A new enzyme superfamily – the phosphopantetheinyl transferases. Chem. Biol. 3, 923936.
  • [9]
    Pappas, K.M., Weingart, C.L., Winans, S.C. (2004) Chemical communication in proteobacteria: biochemical and structural studies of signal synthases and receptors required for intercellular signalling. Mol. Microbiol. 53, 755769.
  • [10]
    Piraee, M., White, R.L., Vining, L.C. (2004) Biosynthesis of the dichloroacetyl component of chloramphenicol in Streptomyces venezuelae ISP5230: genes required for halogenation. Microbiology 150, 8594.
  • [11]
    Quadri, L.E., Weinreb, P.H., Lei, M., Nakano, M.M., Zuber, P., Walsh, C.T. (1998) Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37, 15851595.
  • [12]
    Recio, E., Colinas, A., Rumbero, A., Aparicio, J.F., Martin, J.F. (2004) PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis. J. Biol. Chem. 279, 4158641593.
  • [13]
    Sambrook, J., Fritsch, E.F., Maniatis, T. (1989) Molecular cloning a laboratory manual, 2nd Edn. Spring Harbor Laboratory Press, Cold Cold Spring Harbor, NY.
  • [14]
    Sanchez, C., Du, L., Edwards, D.J., Toney, M.D., Shen, B. (2001) Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC 15003 the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chem. Biol. 8, 725738.
  • [15]
    Sekurova, O., Sletta, H., Ellingsen, T.E., Valla, S., Zotchev, S. (1999) Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC 11455. FEMS Microbiol. Lett. 177, 297304.
  • [16]
    Sekurova, O.N., Brautaset, T., Sletta, H., Borgos, S.E., Jakobsen, Ø.M., Ellingsen, T.E., Strøm, A.R., Valla, S., Zotchev, S.B. (2004) In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. J. Bacteriol. 186, 13451354.
  • [17]
    Sunaga, S., Li, H., Sato, Y., Nakagawa, Y., Matsuyama, T. (2004) Identification and characterization of the pswP gene required for the parallel production of prodigiosin and serrawettin W1 in Serratia marcescens. Microbiol. Immunol. 48, 723728.
  • [18]
    Takano, E., Kinoshita, H., Mersinias, V., Bucca, G., Hotchkiss, G., Nihira, T., Smith, C.P., Bibb, M., Wohlleben, W., Chater, K. (2005) A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor. Mol. Microbiol. 56, 465479.
  • [19]
    Trefzer, A., Pelzer, S., Schimana, J., Stockert, S., Bihlmaier, C., Fiedler, H.P., Welzel, K., Vente, A., Bechthold, A. (2002) Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic. Antimicrob. Agents Chemother. 46, 11741182.
  • [20]
    Walsh, C.T., Gehring, A.M., Weinreb, P.H., Quadri, L.E., Flugel, R.S. (1997) Post-translational modification of polyketide and nonribosomal peptide synthases. Curr. Opin. Chem. Biol. 1, 309315.
  • [21]
    Wang, L., McVey, J., Vining, L.C. (2001) Cloning and functional analysis of a phosphopantetheinyl transferase superfamily gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230. Microbiology 147, 15351545.
  • [22]
    Weissman, K.J., Hong, H., Oliynyk, M., Siskos, A.P., Leadlay, P.F. (2004) Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea. Chembiochem 5, 116125.
  • [23]
    Westrich, L., Domann, S., Faust, B., Bedford, D., Hopwood, D.A., Bechthold, A. (1999) Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis. FEMS Microbiol. Lett. 170, 381387.
  • [24]
    Wyckoff, E.E., Stoebner, J.A., Reed, K.E., Payne, S.M. (1997) Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis. J. Bacteriol. 179, 70557062.
  • [25]
    Zotchev, S.B., Haugan, K., Sekurova, O., Sletta, H., Ellingsen, T.E., Valla, S. (2000) Identification and partial characterization of the gene cluster governing biosynthesis of a novel antibacterial polyketide-derived antibiotic in Streptomyces noursei ATCC 11455. Microbiology 146, 611619.