• [1]
    Rosenthal, P.J., Sijwali, P.S., Singh, A., Shenai, B.R. (2002) Cysteine proteases of malaria parasites: targets for chemotherapy. Curr. Pharm. Des. 8, 16591672.
  • [2]
    Arav-Boger, R., Shapiro, T.A. (2005) Molecular mechanisms of resistance in antimalarial chemotherapy: the unmet challenge. Annu. Rev. Pharmacol. Toxicol. 45, 565585.
  • [3]
    Fidock, D.A., Rosenthal, P.J., Croft, S.L., Brun, R., Nwaka, S. (2004) Antimalarial drug discovery: efficacy models for compound screening. Nat. Rev. Drug Discov. 3, 509520.
  • [4]
    Sijwali, P.S., Rosenthal, P.J. (2004) Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 101, 43844389.
  • [5]
    Shenai, B.R., Sijwali, P.S., Singh, A., Rosenthal, P.J. (2000) Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. J. Biol. Chem. 275, 2900029010.
  • [6]
    Rosenthal, P.J., Olson, J.E., Lee, G.K., Palmer, J.T., Klaus, J.L., Rasnick, D. (1996) Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. Antimicrob. Agents Chemother. 40, 16001603.
  • [7]
    Dominguez, J.N., Lopez, S., Charris, J., Iarruso, L., Lobo, G., Semenov, A., Olson, J.E., Rosenthal, P.J. (1997) Synthesis and antimalarial effects of phenothiazine inhibitors of a Plasmodium falciparum cysteine protease. J. Med. Chem. 40, 27262732.
  • [8]
    Gelhaus, C., Vicik, R., Hilgenfeld, R., Schmidt, C.L., Leippe, M., Schirmeister, T. (2004) Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate. Biol. Chem. 385, 435438.
  • [9]
    Lee, B.J., Singh, A., Chiang, P., Kemp, S.J., Goldman, E.A., Weinhouse, M.I., Vlasuk, G.P., Rosenthal, P.J. (2003) Antimalarial activities of novel synthetic cysteine protease inhibitors. Antimicrob. Agents Chemother. 47, 38103814.
  • [10]
    Olson, J.E., Lee, G.K., Semenov, A., Rosenthal, P.J. (1999) Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors. Bioorg. Med. Chem. 7, 633638.
  • [11]
    Rosenthal, P.J., Lee, G.K., Smith, R.E. (1993) Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J. Clin. Investig. 91, 10521056.
  • [12]
    Singh, A., Shenai, B.R., Choe, Y., Gut, J., Sijwali, P.S., Craik, C.S., Rosenthal, P.J. (2002) Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites. Biochem. J. 368, 273281.
  • [13]
    Reddy, R.C., Vatsala, P.G., Keshamouni, V.G., Padmanaban, G., Rangarajan, P.N. (2005) Curcumin for malaria therapy. Biochem. Biophys. Res. Commun. 326, 472474.
  • [14]
    Joshi, A.A., Narkhede, S.S., Viswanathan, C.L. (2005) Design, synthesis and evaluation of 5-substituted amino-2,4-diamino-8-chloropyrimido-[4,5-b]quinolines as novel antimalarials. Bioorg. Med. Chem. Lett. 15, 7376.
  • [15]
    Humphreys, M.J., Moon, R.P., Klinder, A., Fowler, S.D., Rupp, K., Bur, D., Ridley, R.G., Berry, C. (1999) The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum. FEBS Lett. 463, 4348.
  • [16]
    Magueur, G., Crousse, B., Charneau, S., Grellier, P., Begue, J.P., Bonnet-Delpon, D. (2004) Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate. J. Med. Chem. 47, 26942699.
  • [17]
    Goh, L.L., Loke, P., Singh, M., Sim, T.S. (2003) Soluble expression of a functionally active Plasmodium falciparum falcipain-2 fused to maltose-binding protein in Escherichia coli. Protein Expr. Purif. 32, 194201.
  • [18]
    Zheng, L., Baumann, U., Reymond, J.L.An efficient one-step site-directed and site-saturation mutagenesis protocol Nucleic Acids Res. 32 2004 115
  • [19]
    Shenai, B.R., Rosenthal, P.J. (2002) Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases. Mol. Biochem. Parasitol. 122, 99104.
  • [20]
    Dua, M., Raphael, P., Sijwali, P.S., Rosenthal, P.J., Hanspal, M. (2001) Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1. Mol. Biochem. Parasitol. 116, 9599.
  • [21]
    Goh, L.L., Sim, T.S. (2004) Homology modeling and mutagenesis analyses of Plasmodium falciparum falcipain 2A: implications for rational drug design. Biochem. Biophys. Res. Commun. 323, 565572.
  • [22]
    Rosenthal, P.J. (2004) Cysteine proteases of malaria parasites. Int. J. Parasitol. 34, 14891499.