These authors contributed equally to this work.
Staphylococcal Drp35 is the functional counterpart of the eukaryotic PONs
Article first published online: 9 JAN 2006
FEMS Microbiology Letters
Volume 249, Issue 1, pages 185–190, August 2005
How to Cite
Morikawa, K., Hidaka, T., Murakami, H., Hayashi, H. and Ohta, T. (2005), Staphylococcal Drp35 is the functional counterpart of the eukaryotic PONs. FEMS Microbiology Letters, 249: 185–190. doi: 10.1016/j.femsle.2005.06.038
Edited by M.R. Soria
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 2 April 2005, Revised 7 June 2005, Accepted 9 June 2005
- Staphylococcus aureus;
- Membrane integrity
Drp35 has been identified as a protein that is induced in Staphylococcus aureus in response to exposure to certain antibiotics. Here we demonstrate that Drp35 is a lactonase that does not contribute directly to the resistance to the inducer antibiotics except for bacitracin. The detailed analysis on the expression of Drp35 revealed that in addition to a broad range of antibiotics, agents such as detergents that perturb the membrane integrity could induce its expression. The significance of this characteristic expression is discussed in relation to its activity similarity to the eukaryotic counterparts, paraoxonase family proteins.