These authors contributed equally.
Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)
Article first published online: 9 JAN 2006
FEMS Microbiology Letters
Volume 249, Issue 2, pages 359–366, August 2005
How to Cite
Balbo, M., Barel, M., Lottin-Divoux, S., Jean, D. and Frade, R. (2005), Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21). FEMS Microbiology Letters, 249: 359–366. doi: 10.1016/j.femsle.2005.06.052
Edited by P.W. Andrew
- Issue published online: 9 JAN 2006
- Article first published online: 9 JAN 2006
- Received 21 April 2005, Revised 9 June 2005, Accepted 27 June 2005
- Mycoplasma infection;
- B lymphocyte proliferation;
Human cell lines are often infected by mycoplama strains. We have demonstrated that when infected by Mycoplasma fermentans, human B lymphoma cell proliferation increased strongly. These infected B cells expressed a p45 kDa protein which interacted with the intracellular domain of CD21, the EBV/C3d receptor. p45 analysis demonstrated that this is a new gene which encodes an elongation factor originating from Mycoplasma fermentans. p45 interaction with CD21 was specific, there being no interaction with CD19. This is the first demonstration that Mycoplasma fermentans, in infecting human B cells, generates a p45 Mycoplasma component that interacts with CD21, which is involved in B cell proliferation.