• [1]
    Gombert, A.K., Moreira dos Santos, M., Christensen, B., Nielsen, J. (2001) Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression. J. Bacteriol. 183, 14411451.
  • [2]
    Dos Santos, M.M., Gombert, A.K., Christensen, B., Olsson, L., Nielsen, J. (2003) Identification of in vivo enzyme activities in the cometabolism of glucose and acetate by Saccharomyces cerevisiae by using 13C-labeled substrates. Eukar. Cell 2, 599608.
  • [3]
    Maaheimo, H., Fiaux, J., Çakar, Z.P., Bailey, J.E., Sauer, U., Szyperski, T. (2001) Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional 13C-labeling of common amino acids. Eur. J. Biochem. 268, 24642479.
  • [4]
    Fiaux, J., Çakar, Z.P., Sonderegger, M., Wüthrich, K., Szyperski, T., Sauer, U. (2003) Metabolic flux profiling of the yeasts Saccharomyces cerevisiae and Pichia stipitis. Eukar. Cell 2, 170180.
  • [5]
    Blank, L., Sauer, U. (2004) TCA cycle activity in Saccharomyces cerevisiae is a function of the environmentally determined specific growth and glucose uptake rates. Microbiology 150, 10851093.
  • [6]
    Lange, H.C., Eman, M., van Zuijlen, G., Visser, D., van Dam, J.C., Frank, J., Texeira de Mattos, M.J., Heijnen, J.J. (2001) Improved rapid sampling for in vivo kinetics of intracellular metabolites in Saccharomyces cerevisiae. Biotechnol. Bioeng. 75, 406415.
  • [7]
    van Dam, J.C., Eman, M.R., Frank, J., Lange, H.C., van Dedem, G.W.K., Heijnen, J.J. (2002) Analysis of glycolytic intermediates in Saccharomyces cerevisiae using anion exchange chromatography and electrospray ionization with tandem mass spectrometric detection. Anal. Chim. Acta 460, 209218.
  • [8]
    Szyperski, T. (1998) 13C-NMR, MS and metabolic flux balancing in biotechnology research. Quart. Rev. Phys. 31 41106.
  • [9]
    Dauner, M., Sauer, U. (2000) GC–MS analysis of amino acids rapidly provides rich information for isotopomer balancing. Biotechnol. Prog. 16, 642649.
  • [10]
    Grotkjaer, T., Åkeson, M., Christensen, B., Gombert, A.K., Nielsen, J. (2004) Impact of transamination reactions and protein turnover on labeling dynamics in 13C-labeling experiments. Biotechnol. Bioeng. 86, 209216.
  • [11]
    Verduyn, C., Postma, E., Scheffers, W.A., van Dijken, J.P. (1992) Effect of benzoic acid on metabolic fluxes in yeasts: a continuous culture study on the regulation of respiration and alcoholic fermentation. Yeast 8, 501517.
  • [12]
    van Winden, W.A., Heijnen, J.J., Verheijen, P.J.T., Grievink, J. (2001) A priori analysis of metabolic flux identifiability from 13C-labeling data. Biotechnol. Bioeng. 74, 505516.
  • [13]
    van Winden, W.A., Verheijen, P.J.T., Heijnen, J.J. (2001) Possible pitfalls of flux calculations based on 13C-labeling. Metabol. Eng. 3, 151162.
  • [14]
    Wiechert, W., Möllney, M., Isermann, N., Wurzel, M., de Graaf, A.A. (1999) Bidirectional reaction steps in metabolic networks: III. Explicit solution and analysis of isotopomer labeling systems. Biotechnol. Bioeng. 66, 6985.
  • [15]
    Möllney, M., Wiechert, W., Kownatzki, D., de Graaf, A.A. (1999) Bidirectional reaction steps in metabolic networks: IV. Optimal design of isotopomer labeling experiments. Biotechnol. Bioeng. 66, 86103.
  • [16]
    van Winden, W.A., Wittmann, C., Heinzle, E., Heijnen, J.J. (2002) Correcting mass isotopomer distributions for naturally occurring isotopes. Biotechnol. Bioeng. 80, 477479.
  • [17]
    Mashego, M.R., Wu, L., van Dam, J.C., Ras, C., Vinke, J.L., van Winden, W.A., van Gulik, W.M., Heijnen, J.J. (2004) Miracle: mass isotopomer analysis of 13C-labeled extracts. A new method for accurate quantification of changes of concentrations of intracellular metabolites. Biotechnol. Bioeng. 85, 620628.
  • [18]
    François, J., Parrou, J.L. (2001) Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. FEMS Microbiol. Rev. 25, 125145.
  • [19]
    van der Heijden, R.T.J.M., Heijnen, J.J., Hellinga, C., Romein, B., Luyben, K.Ch.A.M. (1994) Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates. Biotechnol. Bioeng. 43, 310.
  • [20]
    Lange, H.C. (2002) Quantitative Physiology of Saccharomyces cerevisiae using Metabolic Network Analysis. PhD-dissertation Delft University of Technology, Delft, The Netherlands