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Hierarchical and metabolic regulation of glucose influx in starved Saccharomyces cerevisiae

  1. Sergio Rossell,
  2. Coen C. van der Weijden†,
  3. Arthur L. Kruckeberg‡,
  4. Barbara M. Bakker*,
  5. Hans V. Westerhoff

Article first published online: 9 JAN 2006

DOI: 10.1016/j.femsyr.2004.11.003

Issue

FEMS Yeast Research

FEMS Yeast Research

Volume 5, Issue 6-7, pages 611–619, April 2005

Additional Information

How to Cite

Rossell, S., van der Weijden, C. C., Kruckeberg, A. L., Bakker, B. M. and Westerhoff, H. V. (2005), Hierarchical and metabolic regulation of glucose influx in starved Saccharomyces cerevisiae. FEMS Yeast Research, 5: 611–619. doi: 10.1016/j.femsyr.2004.11.003

Author Information

  1. Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, NL-1081 HV, Amsterdam, The Netherlands

  1. †

    1DSM Food Specialties, P.O. Box 1 (pp 0624-0295), 2600 MA, Delft, The Netherlands.

  2. ‡

    Present address: Gothia Yeast Solutions AB, Terrassgatan 7, 41133 Gothenburg, Sweden.

* *Corresponding author. Tel.: +31 20 4447196; fax: +31 20 4447196/4447229, E-mail address: barbara.bakker@falw.vu.nl (B.M. Bakker).

Publication History

  1. Issue published online: 9 JAN 2006
  2. Article first published online: 9 JAN 2006
  3. Received 19 July 2004, Revised 1 November 2004, Accepted 5 November 2004

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Keywords:

  • Functional genomics;
  • Regulation;
  • Starvation;
  • Glucose transport

Abstract

A novel method dissecting the regulation of a cellular function into direct metabolic regulation and hierarchical (e.g., gene-expression) regulation is applied to yeast starved for nitrogen or carbon. Upon nitrogen starvation glucose influx is down-regulated hierarchically. Upon carbon starvation it is down-regulated both metabolically and hierarchically. The method is expounded in terms of its implications for diverse types of regulation. It is also fine-tuned for cases where isoenzymes catalyze the flux through a single metabolic step.

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