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Apoptosis and lipoapoptosis in the fission yeast Schizosaccharomyces pombe

  1. Choon Pei Low1,
  2. Li Phing Liew1,
  3. Shazib Pervaiz2,
  4. Hongyuan Yang1,*

Article first published online: 9 JAN 2006

DOI: 10.1016/j.femsyr.2005.07.004

Issue

FEMS Yeast Research

FEMS Yeast Research

Volume 5, Issue 12, pages 1199–1206, December 2005

Additional Information

How to Cite

Low, C. P., Liew, L. P., Pervaiz, S. and Yang, H. (2005), Apoptosis and lipoapoptosis in the fission yeast Schizosaccharomyces pombe. FEMS Yeast Research, 5: 1199–1206. doi: 10.1016/j.femsyr.2005.07.004

Author Information

  1. 1

    Department of Biochemistry, National University of Singapore, Singapore 119260, Republic of Singapore

  2. 2

    Department of Physiology, National University of Singapore, Singapore 119260, Republic of Singapore

* *Corresponding author. Tel.: +65 6874 7996; fax: +65 6779 1453., E-mail address: bchyangr@nus.edu.sg

Publication History

  1. Issue published online: 9 JAN 2006
  2. Article first published online: 9 JAN 2006
  3. Received 27 May 2005, Revised 5 July 2005, Accepted 20 July 2005

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Keywords:

  • Schizosaccharomyces pombe;
  • Apoptosis;
  • Lipoapoptosis;
  • Diacylglycerols;
  • Triacylglycerols

Abstract

Yeasts being simple eukaryotes are established genetic systems that are often employed to solve important biological questions. Recently, it has become evident that certain cell death programs exist in these unicellular organisms. For example, it has been shown recently that strains of the fission yeast Schizosaccharomyces pombe deficient in triacylglycerol synthesis undergo cell death with prominent apoptotic markers. This minireview is intended to discuss key developments that have rendered fission yeast useful both as a tool and as a model for apoptosis and lipoapoptosis research. It is attempted to delineate a putative signaling pathway leading to the execution of lipoapoptosis in the fission yeast. Although in its infancy, apoptosis research in the fission yeast promises exciting breakthroughs in the near future.

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