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Clinical Management of Intra-Amniotic Infection and Chorioamnionitis: A Review of the Literature


  • Jenifer O. Fahey CNM, MSN, MPH

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    • Jenifer O. Fahey, CNM, MSN, MPH, is an assistant professor and Perinatal Outreach Coordinator at the University of Maryland School of Medicine. In addition to full-scope practice and teaching at the medical school, she is in charge of outreach activities for the Department of Obstetrics and Gynecology, including coordinating telemedicine and simulation programs.

326 Dewey Dr., Annapolis, MD 21401. E-mail:


Intra-amniotic infection (IAI), or chorioamnionitis, complicates up to 10% of all pregnancies and up to 2% of labors at term. There is a significant risk of complications for the mother and the neonate following IAI, including sepsis and pneumonia. In addition, there is a correlation between IAI and premature rupture of membranes, preterm premature rupture of membranes, preterm labor, and preterm birth. Research in the last decade has also revealed a complex and significant association between IAI and cerebral palsy and other central nervous system damage in both the preterm and term fetus. Timely diagnosis and treatment of IAI can significantly reduce the risk of both maternal and neonatal complications.