Relationship Between Vitamin D During Perinatal Development and Health

Authors

  • Jovana Kaludjerovic MSc,

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    • Jovana Kaludjerovic, MSc, is from the Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

  • Reinhold Vieth PhD

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    • Reinhold Vieth, PhD, is from the Department of Pathology and Laboratory Medicine, University of Toronto, and Mount Sinai Hospital, Toronto, Ontario, Canada.


Address correspondence to Jovana Kaludjerovic, MSc, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, FitzGerald Bldg., 150 College St., Toronto, Ontario, Canada M5S 3E2. jovana.kaludjerovic@utoronto.ca

Abstract

Vitamin D deficiency is a highly prevalent condition that is present in 40% to 80% of pregnant women. There is emerging evidence that vitamin D deficiency may be a risk modifying factor for many chronic diseases, including osteomalacia, rickets, multiple sclerosis, schizophrenia, heart disease, type 1 diabetes, and cancer. Heightened susceptibility to these diseases may originate in early life during the development of tissue structure and function. It is suspected that biologic mechanisms can “memorize” the metabolic effects of early nutritional environment through fetal and neonatal imprinting. Inadequate vitamin D nutrition during perinatal life may establish a poor foundation that may produce long-term threats to human health. This review summarizes the risks of vitamin D deficiency for human health and provides the current vitamin D recommendations for mothers and their newborns.

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