Advancing technology changes the very nature of the world in which we interact. Often these changes introduce unintended stresses and strains on the individual attempting to interact with this new technology. The objective of this 17-chapter edited volume is to promote engineering psychophysiology as a discipline that uses a variety of psychophysiological measures to understand and potentially improve the nature of our interactions in the real world. The target audience for the book is the researcher who is new to the use of psychophysiological measures in engineering applications.