Role of Caco-2 Cell Monolayers in Prediction of Intestinal Drug Absorption

Authors

  • Pranav Shah,

    1. Department of Pharmacy, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Post Box 51, Kalabhavan, Vadodara 390 001, India
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  • Viral Jogani,

    1. Department of Pharmacy, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Post Box 51, Kalabhavan, Vadodara 390 001, India
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  • Tamishraha Bagchi,

    1. Department of Microbiology and Biotechnology Centre, Faculty of Science, The Maharaja Sayajirao University of Baroda, Sayajigunj, Vadodara 390 002, India
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  • Ambikanandan Misra

    Corresponding author
    1. Department of Pharmacy, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Post Box 51, Kalabhavan, Vadodara 390 001, India
    • Department of Pharmacy, Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Post Box 51, Kalabhavan, Vadodara 390 001, India. Tel: +91–265–2434187. Fax: +91–265–2418927
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Abstract

The usefulness of Caco-2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco-2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.

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